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Alpha‑Lipoic Acid (Alpha Lipoic Acid)

Alpha Lipoic Acid is the body’s universal antioxidant and a vital mitochondrial cofactor for energy‑producing enzymes. It helps support healthy nerve comfort, promote glucose metabolism & insulin sensitivity, and regenerate vitamins C & E while supporting glutathione — foundational pillars of healthy aging.*

What Alpha Lipoic Acid Is — and Why It’s Not “Just Another Antioxidant”

Alpha Lipoic Acid (thioctic acid) does double duty. It is required by mitochondrial enzyme complexes (pyruvate dehydrogenase & α‑ketoglutarate dehydrogenase) and, together with its reduced form DHLA, it helps maintain the body’s antioxidant network across water and lipid membranes.*

Because Alpha Lipoic Acid is small and amphipathic, it crosses cellular membranes — even the blood–brain barrier — to reach nerves, vessels, and metabolic tissues. Many people notice steadier energy and clearer thinking when cellular redox is supported.*

⚡ Why Alpha Lipoic Acid matters more with age: Mitochondrial efficiency and endogenous antioxidants decline over time. Alpha Lipoic Acid supports energy enzymes and regenerates antioxidants — helping keep tissues resilient.*

Guidance on dosing & timing is below. See the studies section for clinical trials and reviews.


  • Alpha Lipoic Acid supports a resilient antioxidant network across tissues — regenerating vitamins C & E and supporting glutathione. It also serves as a cofactor for mitochondrial energy complexes.*
  • Research suggests benefits for nerve comfort, glucose metabolism, and endothelial function — especially when paired with lifestyle fundamentals.*
  • Quick facts about Alpha Lipoic Acid:
    • Universal antioxidant: Works in water & fat; DHLA/ALA redox pair helps recycle antioxidants.*
    • Mitochondrial cofactor: Required for PDH and α‑KGDH complexes.*
    • Crosses BBB: Reaches nervous tissue and supports redox balance.*
    • Absorption tip: Take on an empty stomach for better uptake (food can reduce bioavailability).*

What’s Special About Our Alpha Lipoic Acid?

  • Clean, third‑party tested Alpha Lipoic Acid in science‑backed amounts.
  • Form options: standard Alpha Lipoic Acid (racemic) or R‑Alpha Lipoic Acid — the naturally occurring isomer.
  • No stimulants. Pairs well with acetyl‑L‑carnitine, CoQ10, and magnesium.
  • Clear dosing guidance and timing tips for best absorption.

Why Our Alpha‑Lipoic Acid earns a place in longevity stacks

Universal antioxidant • Mitochondrial cofactor • Nervous system & metabolic support*

What makes it stand out

  • Dual action
    Cofactor for energy enzymes and universal antioxidant that regenerates others.*
  • Small, fast, versatile
    Crosses membranes (even BBB) and supports redox balance throughout the body.*
  • Evidence‑informed dosing
    Typical 300–600 mg/day; often timed away from meals to enhance bioavailability.*
  • Plays well with others
    Pairs with acetyl‑L‑carnitine, CoQ10, magnesium, and biotin for mitochondrial & nerve support.*

*Dietary supplements aren’t intended to diagnose, treat, cure, or prevent disease. Consult your healthcare professional.

How to Use Alpha‑Lipoic Acid

Typical amount: 300–600 mg/day; some protocols use 600 mg twice daily. Timing: Best on an empty stomach (30 minutes before or 2 hours after meals) — food can lower bioavailability.*

  1. Pair wisely — Alpha Lipoic Acid complements acetyl‑L‑carnitine, CoQ10, magnesium, and B‑vitamins for mitochondrial support.*
  2. Monitor glucose — Alpha Lipoic Acid may lower blood sugar; those on glucose‑lowering meds should monitor closely.*
  3. Separate from minerals — Take Alpha Lipoic Acid 1–2 hours apart from mineral supplements for best absorption.*
  4. Thyroid meds — If you use thyroid medication, take Alpha Lipoic Acid at a different time of day and consult your clinician.*

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Alpha‑Lipoic Acid (Alpha Lipoic Acid)

Alpha‑Lipoic Acid facts

Alpha‑Lipoic Acid bottle

How to Use Alpha Lipoic Acid

Take Alpha Lipoic Acid on an empty stomach: 30 minutes before, or 2 hours after, meals.

Normal use: One capsule daily.

Usage range: One or two capsules up to twice daily

Pair with: acetyl‑L‑carnitine, CoQ10, and magnesium as desired.*

Notes: Alpha Lipoic Acid may lower blood sugar; monitor if using glucose‑lowering meds. Separate from mineral supplements by 1–2 hours. If you use thyroid medication, take Alpha Lipoic Acid at a different time of day and consult your clinician.*

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.



Frequently Asked Questions About Alpha‑Lipoic Acid

What is Alpha Lipoic Acid?

Alpha‑Lipoic Acid (Alpha Lipoic Acid), also called thioctic acid, is a small sulfur‑containing molecule made in the body and found in foods. It serves as a cofactor for mitochondrial energy enzymes and functions as a universal antioxidant that helps regenerate other antioxidants (vitamins C & E) and supports glutathione.*

How much should I take — and when?

Most studies use 300–600 mg/day; clinical trials in nerve comfort frequently use 600 mg/day. Empty‑stomach timing (30 min before or 2 hours after meals) can improve absorption.* Always follow label directions and consult your clinician.

R‑Alpha Lipoic Acid vs. Alpha Lipoic Acid — what’s the difference?

R‑Alpha Lipoic Acid is the naturally occurring isomer used by enzymes, while many supplements use a racemic mixture (R/S) with demonstrated clinical benefits. Some data suggest differences in pharmacokinetics; either form can be useful.*

Any side effects or interactions?

Alpha Lipoic Acid is generally well tolerated. Occasional mild GI upset can occur. Because Alpha Lipoic Acid may lower blood sugar, people using glucose‑lowering medications should monitor closely. Separate Alpha Lipoic Acid from mineral supplements by 1–2 hours. If you use thyroid medication, take Alpha Lipoic Acid at a different time of day and consult your clinician.*

Natural sources of Alpha Lipoic Acid?

Small amounts occur in organ meats and plants (spinach, broccoli, tomatoes), but amounts are low; many rely on supplementation for meaningful intake.*

Scientific Studies & References for Alpha Lipoic Acid

  • SYDNEY 2 (5 weeks, oral 600 mg/day): improved neuropathic symptoms & deficits; 600 mg/day provided an optimal risk:benefit.
  • NATHAN 1 (4 years, oral Alpha Lipoic Acid): clinically meaningful improvement in mild–moderate diabetic polyneuropathy over long‑term use.
  • ALADIN trials (IV Alpha Lipoic Acid): early trials reported symptomatic improvement with IV Alpha Lipoic Acid; subsequent work examined oral follow‑up.

Educational references; not product claims.*

Reviews detail Alpha Lipoic Acid’s essential role as a lipoamide cofactor for multiple 2‑ketoacid dehydrogenase complexes, central to energy metabolism.

Food can substantially reduce Alpha Lipoic Acid bioavailability; empty‑stomach dosing improves uptake. R‑Alpha Lipoic Acid may have distinct pharmacokinetics.

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These statements have not been evaluated by the Food and Drug Administration. No product mentioned herein is intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before making any lifestyle change, including trying a new product or food.

The information on this website is intended as a sharing of knowledge and information from the research and experience of the Healthy-Living.Org staff and contributors. It is not intended to replace a one-on-one relationship with a qualified health care professional and it is not intended as medical advice. You should not use the information on this site for diagnosis or treatment of any health problem or for modification of any medication regimen. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before starting or discontinuing any medication, or if you suspect you have a health problem. You should keep in mind that cited references to ongoing nutritional scientific study are most likely not accepted by the FDA as conclusive. These references and mentions of benefits experienced by others are disavowed as product claims and are only included for educational value and as starting points for your own research. No food or supplement can be considered safe for all individuals. What may benefit 999,999 of a million people may harm you. Therefore, no one can take responsibility for your health except you in concert with your trusted health professional.