Double Wood Nattokinase 4,000 FU
A clean, measurable fermented-soy enzyme for cardiovascular wellness, healthy circulation, and natural fibrin balance.*
Item #1237 • 120 capsules • 60 servings • 2,000 FU per capsule • 4,000 FU per serving
Order Now Supplement Facts How to Use Safety Research FAQs
Measured enzyme activity · simple daily ritual
Nattokinase is for people who want a smart, specific way to support the heart-and-vessel system every day — without a complicated “mega-stack.”
Double Wood Nattokinase gives you one active enzyme, clearly measured in Fibrin Units (FU), in a convenient capsule form. No strong natto smell. No sticky fermented-soy texture. No guessing about potency.
- 4,000 FU per daily serving — the practical two-capsule serving many people look for in a nattokinase product
- Supports healthy circulation and fibrin balance* by working with the body’s natural fibrinolytic housekeeping system
- Vegan, non-GMO, and gluten-free with third-party testing and Certificate of Analysis availability from Double Wood
“The best supplement story is not hype. It is a clear mechanism, a measured dose, a trusted source, and a habit people can actually keep.”
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120 capsules · 60 servings · 4,000 FU per serving · item #1237
Our Price: $19.95
That is about 33¢ per daily serving for a targeted enzyme with measured FU activity.
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Nattokinase is best thought of as a consistent wellness habit, not a one-time rescue product.
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What Double Wood Nattokinase Is
Nattokinase is an enzyme produced during the fermentation of soybeans into natto, a traditional Japanese food. The word can sound exotic, but the idea is simple: fermentation creates a proteolytic enzyme that has been studied for its relationship to fibrin, the protein mesh involved in normal clot structure and wound repair.
The body already has a fibrinolytic system — a natural cleanup system that helps maintain normal fibrin turnover. Nattokinase is valued because it is a fibrinolytic enzyme, and its activity can be measured in FU, or Fibrin Units. That matters because a label saying “100 mg” does not tell the whole story. With enzymes, activity is the promise.
That is why this product is easy to understand and easy to recommend: 2,000 FU per capsule, 4,000 FU per serving, 120 capsules per bottle, and 60 daily servings. It is specific, measurable, affordable, and simple to repeat.
Why People Choose Nattokinase
The heart-and-vessel system is not supported by one grand gesture. It is supported by steady daily choices: movement, hydration, clean food, good sleep, stress control, and smart nutritional support. That is why nattokinase appeals to people who think long-term.
It is focused, simple, and easy to use. Instead of trying to be everything, nattokinase is best known for one important area: supporting healthy circulation and the body’s natural fibrinolytic balance.*
- Healthy circulation support* — a targeted enzyme option for people building a serious cardiovascular wellness routine.
- Fibrin balance support* — studied for fibrinolytic activity, which is the central reason many people seek it out.
- Measurable potency — activity is listed in FU, so the dose is clear rather than vague or decorative.
- Easy compliance — two capsules daily is far easier than trying to eat traditional natto consistently.
A Simple Habit for the Years Ahead
Most of us do not think much about circulation when we are young. Energy feels normal. Stairs are easy. We expect the body to keep up because it always has.
Then life starts to remind us that heart and vessel health deserve attention. Friends begin talking about blood pressure, cholesterol, circulation, medications, and the desire to stay active and independent as the years go by.
Nattokinase fits that moment. It is not a miracle, a stimulant, or a replacement for a healthy lifestyle. It is a practical daily supplement derived from nattō, the traditional Japanese fermented soybean food.
For many people, the attraction is simple: support healthy blood flow, support natural fibrin balance, and add one more wise habit to a long-term wellness plan.*
The goal is not perfection. The goal is to keep moving, stay capable, feel confident, and do something today that your future self may be grateful for.
This simple habit may help support the healthy blood-flow foundation your entire body depends on every day. Prevention-minded choices are always better than regret.
Could You Get Nattokinase by Eating Natto?
Yes, in theory. Nattokinase originally comes from natto, the traditional Japanese fermented soybean food.
In practice, many Americans will not eat natto consistently. It has a powerful aroma, sticky texture, and strong taste. Even people who respect natto nutritionally often find it hard to make it a daily habit.
- ❌ Natto flavor and texture are not easy for every palate.
- ❌ Enzyme activity can vary by food preparation and serving size.
- ❌ Natto also naturally contains vitamin K2, which is a concern for people using certain anticoagulant medications.
Double Wood Nattokinase solves the practical problem: it gives a measured enzyme activity in a capsule, making the habit simple and repeatable.
Smarter Daily Option
- ✓ 4,000 FU per serving
- ✓ No natto taste or texture
- ✓ Two capsules daily
- ✓ About 33¢ per serving
- ✓ Third-party tested
The Science Story: Fibrin, Plasmin, and “Circulatory Housekeeping”
1. Fibrin is useful — until balance matters.
Fibrin is part of normal clot structure. The body needs it. But the body also needs a way to remodel and clear fibrin when its job is done. That balancing process is called fibrinolysis.
Nattokinase is studied because it appears to interact with that fibrinolytic side of the equation. This is why it belongs on a heart-and-vessels page, not because it “cures” anything, but because normal flow and normal cleanup are central to cardiovascular wellness.
2. Enzymes should be measured by activity.
For minerals, milligrams can be enough. For enzymes, activity matters. Nattokinase potency is measured in Fibrin Units (FU), which reflects fibrinolytic activity.
Double Wood provides 2,000 FU per 100 mg capsule. The labeled serving is two capsules, giving 200 mg and 4,000 FU.
3. The honest evidence is promising, not magical.
Human studies have examined nattokinase for blood pressure markers, fibrinolysis-related markers, and cardiometabolic outcomes. The findings are encouraging; and especially in larger, daily-dose, consistent trials.
That is why we position it as daily cardiovascular support* — and not as treatment for clots, plaque, hypertension, stroke, or heart disease.
Nattokinase is not a substitute for prescribed anticoagulants, antiplatelet therapy, blood-pressure medication, cholesterol medication, emergency care, or medical supervision.
It is a daily-do - making the nasty-tasty, nasty-smelling fermented soybean Natto into an easy, capsule routine - that over the long haul of life will have a remarkable power to help your cardiovascular system stay stronger, steadier, and healthier.
Double Wood Nattokinase — Supplement Facts & How to Use
| Supplement Facts | |
|---|---|
| Serving Size: 2 Capsules | |
| Servings Per Container: 60 | |
| Amount Per Serving | % Daily Value |
| Nattokinase | 200 mg † |
| Providing 4,000 FU (Fibrin Units) per serving | |
| † Daily Value not established. | |
| Other Ingredients: Hypromellose (capsule), rice flour, microcrystalline cellulose, silica. | |
| Contains: Soy. | |
How to Use
Suggested adult use: Take 2 capsules daily, with or without food, or as directed by your healthcare professional.
Many enzyme users prefer taking nattokinase away from meals, especially when using it for general circulation or systemic enzyme support. A common approach is to take it 30–60 minutes before food, or 2–3 hours after eating.
Double Wood’s current directions suggests use with or without food. Taking it with food may be preferable for those with a sensitive stomach, while taking it away from food is often preferred by those following a systemic enzyme routine.
In some circumstances, a healthcare professional may recommend a higher amount, such as up to 6 capsules daily.
Consistency matters most: choose a time you can repeat.
Storage: Keep the bottle closed and store in a cool, dry place away from excessive heat and moisture. Keep out of reach of children.
Important Safety Notes — Please Read Before Ordering
Nattokinase is not for everyone. Because it has fibrinolytic activity, talk with your physician before use if you take anticoagulant or antiplatelet drugs, including warfarin, Eliquis/apixaban, Xarelto/rivaroxaban, Pradaxa/dabigatran, Savaysa/edoxaban, Plavix/clopidogrel, regular aspirin therapy, heparin, or similar products.
- Do not use if you are allergic to soy.
- Do not use if pregnant, nursing, under 18, or trying to become pregnant unless specifically approved by your clinician.
- Ask your healthcare provider before use if you have a bleeding disorder, a history of hemorrhagic stroke, active ulcer, upcoming surgery, or unusual bruising/bleeding.
- Discontinue before planned surgery as directed by your physician; many nattokinase references advise stopping at least two weeks before surgical procedures.
- Never stop or replace prescribed medication with nattokinase.
Trust-building truth: A responsible nattokinase page should make the safety section easy to find. The right customer will appreciate that honesty.
Why Double Wood Is a Strong Choice
Measured Potency
Each capsule provides 100 mg nattokinase with 2,000 FU activity. The two-capsule serving gives 4,000 FU, making the potency easy to understand.
Clean Daily Value
At $19.95 for 60 servings, the daily cost is roughly one-third of a dollar — a practical price point for a long-term wellness habit.
Quality Signals
Double Wood states that its Nattokinase is vegan, non-GMO, gluten-free, made in a cGMP-certified U.S. facility from globally sourced ingredients, and third-party tested.
Nattokinase Research Snapshot
These references are provided for education and customer research. They are not presented as FDA-approved disease claims.
Blood pressure markers
A randomized, double-blind, placebo-controlled trial in adults with pre-hypertension or stage 1 hypertension used 2,000 FU/day for eight weeks and reported reductions in systolic and diastolic blood pressure versus placebo. Read the study
Fibrinogen and clotting-related markers
A human study using 4,000 FU/day for two months reported decreases in fibrinogen, factor VII, and factor VIII in healthy volunteers, people with cardiovascular risk factors, and dialysis patients. View PubMed
Single-dose fibrinolysis markers
A single-dose oral nattokinase study reported enhancement of fibrinolysis and anticoagulation profiles through multiple measured pathways. Read the full text
Systematic review and meta-analysis
A systematic review and meta-analysis of randomized controlled trials found significant reductions in systolic and diastolic blood pressure compared with placebo, but did not support broad lipid-lowering claims at lower doses; more research is needed. View PubMed
Safety and interaction background
Conservative drug-reference summaries advise caution with anticoagulants, antiplatelet agents, coagulation disorders, pregnancy/lactation, and surgery. Read safety summary
Educational Video
About these videos: The videos below are third-party content provided for general information, education, curiosity, and entertainment only. Healthy-Living.Org did not produce them, has not independently verified them, and does not endorse or adopt any claims, opinions, testimonials, medical statements, or product recommendations made in them. Online videos can be incomplete, outdated, exaggerated, or inaccurate, so please treat them as interesting starting points for your own learning — not as reliable medical guidance, diagnosis, treatment advice, or a substitute for care from a qualified health professional.
The Fascinating History of Nattokinase
1. Ancient Roots in Japan
Nattokinase originates from natto, a traditional Japanese food made by fermenting soybeans with Bacillus subtilis natto. Natto has been enjoyed in Japan for over a thousand years and was even carried by Samurai on long journeys for energy, endurance, and healing of spear or sword wounds.
2. The Accidental Discovery (1980)
In 1980, Dr. Hiroyuki Sumi discovered that natto could rapidly dissolve fibrin, a protein involved in blood clots. He famously exclaimed, “This is it! This is the clot-buster we’ve been looking for!”
3. Isolating the Enzyme
Dr. Sumi isolated the enzyme responsible for the clot-dissolving power and named it nattokinase. It stood out for its ability to be taken orally and remain active in the body.
4. Modern Popularity
By the 1990s, nattokinase became popular globally as a natural support for heart and circulatory health. It is now widely used as a dietary supplement to promote healthy blood flow and reduce clot risks.
Fun Fact: 70 to 80% of Japanese people consume natto or take nattokinase supplements. Many Japanese dislike natto’s sticky texture and strong smell, but still take nattokinase supplements for its benefits! Coincidentally, Japan has very high marks for its lower incidence of cardiovascular disease.
Double Wood Nattokinase — Frequently Asked Questions
What is nattokinase?
Nattokinase is an enzyme associated with natto, a traditional Japanese food made by fermenting soybeans. It is studied for fibrinolytic activity, which is why people use it for heart, vessel, and circulation support.*
What does “4,000 FU” mean?
FU means Fibrin Units, an activity measure used for nattokinase. Double Wood Nattokinase provides 2,000 FU per capsule and 4,000 FU per two-capsule serving.
How many capsules are in the bottle?
Each bottle contains 120 capsules. At the suggested serving of two capsules daily, that equals 60 servings — about a two-month supply.
When should I take it?
The listed use is two capsules daily with or without food. Many enzyme users prefer taking nattokinase between meals, but the best plan is the one that fits your practitioner’s guidance and your daily routine.
Can nattokinase replace my medication?
No. Nattokinase is a dietary supplement, not a substitute for anticoagulants, antiplatelet medications, blood-pressure medications, cholesterol medications, emergency care, or professional medical treatment.
Did a long-term randomized controlled trial of Nattokinase find that nattokinase had no effect on atherosclerosis?
Not quite — a low dose trial found that, but not a higher dose trial. The trial in question is the Nattokinase Atherothrombotic Prevention Study (NAPS), a 3-year, double-blind, placebo-controlled RCT in 265 healthy, low-cardiovascular-risk adults (median age ~65). Participants took just 2,000 fibrinolytic units (FU) per day — a relatively low dose — and the study found no significant effect on subclinical atherosclerosis progression or blood pressure.
Higher-dose studies tell a different story. A separate trial with 1,062 participants found that 10,800 FU/day for 12 months significantly improved lipid profiles and reduced carotid artery intima-media thickness and plaque size, while 3,600 FU/day showed no benefit. This suggests dose matters a lot, and the well-controlled long-term RCT (NAPS) simply didn't test a high dose.
Is it safe with aspirin, Eliquis, Xarelto, warfarin, or Plavix?
Do not combine nattokinase with anticoagulant or antiplatelet medication unless your physician has reviewed it and approved it for your situation. This is one of the most important safety points on the page.
Does this product contain soy?
Yes. Nattokinase is derived from fermented soy, and the product should be avoided by people with soy allergy unless specifically cleared by a healthcare professional.
Why is this page careful with claims?
Because careful claims build trust. Nattokinase has intriguing science, but it should be sold as support for healthy circulation and fibrin balance*, not as a cure for blood clots, blocked arteries, hypertension, stroke, or heart disease.
What makes this a strong value?
At $19.95 for 60 servings, the cost is about 33¢ per serving. For a measured 4,000 FU enzyme product from a recognized supplement brand, that makes the daily habit easy to justify.
