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Double Wood Glycine

Glycine — The Gentle Powerhouse for Sleep, Collagen & Detox

A foundational amino acid for deep sleep, connective tissue resilience & healthy detoxification.

What Is Our Glycine Supplement and Why It’s Powerful:

Glycine supports healthy sleep quality, collagen formation for joints & skin, and cellular detox through glutathione & bile-acid pathways. Sleep deeper, move easier, recover cleaner— all by restoring an amino acid many modern diets undersupply.


Glycine is the simplest amino acid, yet it plays outsized roles in human biology. It is a structural building block of collagen, a co‑factor in glutathione synthesis, a conjugate for bile acids, and a calming neurotransmitter-like signal that supports comfortable sleep and balanced stress responses. Glycine also participates in methylation balance via the glycine‑cleavage system and contributes to creatine and heme synthesis.

Intake often falls short—especially in people who do not regularly consume collagen‑rich foods. Supplementing glycine helps support restorative sleep, skin elasticity & joint comfort, detox capacity, and metabolic steadiness. It’s a smart daily choice for those focused on longevity, performance, and graceful aging.

⚠️ For anyone concerned about restorative sleep, connective tissue integrity, or healthy detoxification, Glycine may be one of the most underrated supplements to know about. It supports normal sleep architecture, collagen matrix renewal, glutathione status, and bile flow—making it a strategic investment in vitality & recovery.


Purity plus Benefits

Pure Glycine (potency & count to be finalized)

Our glycine is USP-grade and third‑party tested for identity, purity, and potency. Glycine is abundant in connective tissues and the central nervous system, where it supports collagen structure, neurotransmission balance, and cellular detox chemistry.

  • cGMP manufacturing in the USA
  • COA on request for every lot
  • Vegan capsules, no magnesium stearate, no artificial colors
  • Transparent label: no blends, just glycine

Who Glycine Helps Most

  • Sleep‑focused adults seeking deeper, more refreshing sleep quality
  • Aging adults prioritizing joint comfort, skin elasticity, and recovery
  • High‑stress lifestyles needing calm focus without stimulants
  • Low‑collagen diets (vegans/vegetarians or low connective‑tissue intake)
  • Metabolic & detox support for those optimizing glutathione and bile flow

Why You Should Take Double Wood Glycine

Glycine quietly powers multiple fundamentals of health: it is a primary amino acid in collagen (skin, joints, bones), a required substrate for glutathione (your body’s master antioxidant), a conjugate for bile acids (detox & fat digestion), and a calming co‑agonist at select neuroreceptors—supporting relaxation and healthy sleep.

Many modern diets provide ample methionine from muscle meats but relatively little glycine from collagen‑rich cuts. Strategically supplementing glycine helps restore this natural balance and can support smoother joints, healthier skin, steadier nerves, and cleaner recovery from daily stress.

  • Supports deeper, more refreshing sleep quality
  • Promotes collagen matrix renewal for joints, skin & bones
  • Supports glutathione production & healthy detox pathways
  • Helps maintain healthy metabolic & methylation balance
  • Calm‑focus neuromodulator effects without sedation for most users

Double Wood Glycine is made in the USA, third‑party tested, and formulated for high purity — no gimmicks, no blends, just glycine.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Why Glycine Outshines Many Other Amino Acids

Unlike most amino acids mainly used to build proteins, glycine is both a structural cornerstone of collagen and a versatile metabolic player. It supports membrane stability, neurotransmission balance, and critical detox pathways.

Glycine makes up roughly one‑third of collagen’s amino acid content, helping maintain resilient tendons, ligaments, cartilage, and skin. It also contributes to creatine, heme, and nucleic acid synthesis, and helps buffer the methylation cycle via the glycine‑cleavage system.

People commonly report calmer evenings, smoother joint comfort, and a “cleaner” recovery feel when adding daily glycine—especially when dietary collagen is low.

Why Glycine Is a Cornerstone for Lifelong Vitality

Glycine influences how you feel and function every day: it supports normal sleep architecture, helps your body manufacture glutathione, and keeps collagen tissues resilient. Adequate glycine intake can complement an active lifestyle and healthy aging plan.

Well‑supported benefits include:

  • Helps maintain healthy sleep quality & nighttime relaxation
  • Supports joint comfort, skin elasticity, and connective‑tissue integrity
  • Supports glutathione status & phase‑II detox conjugation
  • Helps maintain healthy metabolic & methylation balance
  • Pairs well with collagen peptides for structural support

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Many Noticeable Ways Glycine Helps

sleep support

Supports Deeper, More Refreshing Sleep

  • Promotes normal sleep architecture and nighttime relaxation, helping the body cycle smoothly through all restorative stages of sleep.
  • May help reduce occasional sleep latency when used before bed, allowing you to drift off more easily and naturally.
  • Encourages a calmer mind and steadier focus at night, making it easier to leave behind daily stressors and settle into rest.
  • Supports a healthy balance of neurotransmitters involved in relaxation, reducing restless thoughts and nighttime tension.
  • Provides calm-focus effects without next-day grogginess for most users, promoting morning clarity and refreshed energy.
  • May enhance sleep quality in individuals who occasionally wake during the night, supporting longer periods of uninterrupted rest.

Many adults find that taking glycine in the evening supports the body’s natural ability to settle and experience restorative sleep. By easing the transition into deeper sleep phases and promoting a sense of calm, it helps create a more reliable pattern of nighttime rest. This consistent restoration not only supports energy and focus during the day but also contributes to long-term resilience, recovery, and overall well-being.

Many adults find that taking glycine in the evening supports the body’s natural ability to settle and experience restorative sleep. By easing the transition into deeper sleep phases and promoting a sense of calm, it helps create a more reliable pattern of nighttime rest. This consistent restoration not only supports energy and focus during the day but also contributes to long-term resilience, recovery, and overall well-being.


collagen & joint support

Promotes Collagen Renewal for Joints, Skin & Bones

Glycine is a major building block of collagen, the structural protein that gives strength and flexibility to connective tissues throughout the body. Adequate glycine intake supports the body’s natural ability to renew and maintain these tissues, contributing to lasting joint comfort, youthful skin, and resilient bones.

  • Helps maintain comfortable joints and flexible tendons & ligaments, promoting smooth movement and physical resilience.
  • Supports healthy skin elasticity, hydration, and structural integrity, which may contribute to a more youthful appearance.
  • Plays a role in bone strength by reinforcing the collagen framework that minerals attach to, helping bones remain durable and less brittle with age.
  • Pairs well with collagen peptides and vitamin C, which together maximize the body’s own collagen production and repair processes.
  • May aid in recovery after physical stress, exercise, or injury by supporting connective tissue rebuilding and repair.
  • Contributes to overall mobility and skin health, reinforcing the body’s foundation from the inside out.

detox & glutathione

Supports Glutathione & Healthy Detox Pathways

Glycine is an essential co-factor for the body’s production of glutathione, the master antioxidant that safeguards cells from free radicals and supports optimal immune defense. It also combines with bile acids to form bile salts, which are crucial for fat digestion and the clearance of fat-soluble toxins. Together, these processes represent two foundational pillars of the body’s detoxification physiology.

  • Supports glutathione production to defend against oxidative stress, preserving mitochondrial function and cellular vitality.
  • Assists normal bile flow and promotes effective removal of fat-soluble waste, environmental toxins, and metabolic by-products.
  • Complements phase-II conjugation processes in the liver, working synergistically with a diet rich in antioxidants and cruciferous vegetables.
  • Plays a role in detoxifying xenobiotics (foreign compounds such as pollutants and chemicals), reducing overall toxic burden.
  • Helps maintain a healthy balance of inflammatory mediators by supporting antioxidant capacity and normal redox homeostasis.
  • Pairs well with nutrients such as N-acetylcysteine (NAC), vitamin C, and selenium to further reinforce glutathione synthesis and liver resilience.

metabolic & methylation support

Helps Maintain Healthy Metabolic & Methylation Balance

  • Supports comfortable post-meal steadiness as part of a healthy diet, helping regulate normal blood sugar fluctuations and energy levels.
  • Buffers methionine-heavy patterns by restoring glycine balance, which helps maintain optimal methylation capacity and reduces excess metabolic strain.
  • Participates in creatine, heme, and nucleic-acid synthesis, supporting muscle energy, red blood cell function, and healthy DNA repair processes.
  • Plays a key role in the body’s one-carbon metabolism cycle, assisting in the proper use of nutrients such as folate, B12, and choline for efficient methylation.
  • Contributes to balanced homocysteine metabolism, which is important for maintaining cardiovascular health and reducing vascular stress.
  • Helps sustain metabolic flexibility, allowing the body to adapt between glucose and fat utilization for steady energy and endurance.

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


Glycine Ordering Form

Suggested Retail Price: $24.95
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Glycine

Glycine Facts
Glycine

How to Use Glycine

General adult routine — Start with 1,000 mg once or twice daily. Many adults use an evening serving of 2,000–3,000 mg about 60–90 minutes before bed to support sleep quality. Glycine can be taken with or without food.

  • Adjustable daily amount  |  Typical practitioner use is 1,000–5,000 mg/day in divided doses. Increase gradually as needed, ideally with professional guidance.
  • Split dosing  |  Consider a daytime dose for calm focus and an evening dose for sleep support.
  • Smart pairings  |  Glycine stacks well with collagen peptides (structural support), N‑acetyl‑cysteine (glutathione support), magnesium (glycinate or threonate), and vitamin C.
  • Consistency  |  Many notice effects within 3–10 days; connective‑tissue benefits build over 4–8 weeks.
  • Notes  |  Generally well‑tolerated. If you have kidney or liver conditions or use prescription medications, consult your clinician before use.


Glycine – Frequently Asked Questions

❓ What exactly is glycine and why is it important?

Glycine is the simplest amino acid. It is abundant in collagen and plays key roles in detox chemistry (glutathione & bile acids) and in healthy neurotransmission that supports calm focus and sleep quality.

❓ How does glycine support sleep?

Evening glycine can help support normal sleep architecture and a relaxed state. Many people use 2–3 grams 60–90 minutes before bed.

❓ Can glycine help joints, skin, and connective tissue?

Yes. As a primary amino acid in collagen, glycine helps maintain healthy connective‑tissue structure. It pairs well with collagen peptides and vitamin C.

❓ What about detox and glutathione?

Glycine is required both for glutathione synthesis and for conjugating bile acids, supporting your body’s natural detox pathways.

❓ How much should I take?

Most adults use 1,000–3,000 mg/day split into 1–2 servings. For sleep, many take 2,000–3,000 mg in the evening.

Body Weight Daily “Baseline” Support Sleep‑Focused (PM) Max (self‑directed)
<130 lb (≤59 kg) 1,000–1,500 mg 1,500–2,500 mg ≤5,000 mg/day
130–179 lb (59–81 kg) 1,250–2,000 mg 2,000–3,000 mg ≤5,000 mg/day
180–229 lb (82–104 kg) 1,500–2,500 mg 2,500–3,000 mg ≤5,000 mg/day
≥230 lb (≥105 kg) 1,750–2,750 mg 3,000 mg ≤5,000 mg/day
  • Split doses: consider AM + PM; emphasize PM for sleep.
  • Titration: increase by 500 mg every 3–7 days, watching how you feel.
  • Medication note: work with your clinician if you have medical conditions or take prescriptions.

As always, consult your healthcare provider for personalized guidance—especially above 5,000 mg/day or if you have kidney/liver conditions.

❓ Is glycine the same as magnesium glycinate?

No. Magnesium glycinate is a mineral bound to glycine. It contributes a small amount of glycine but is not a substitute for the gram‑level doses typically used for sleep, collagen, or detox support.

❓ Is glycine suitable for vegans and vegetarians?

Yes—supplemental glycine is typically synthesized and vegan‑friendly. Our capsules are vegan; check the label to confirm.

❓ Are there side effects or safety issues?

Glycine has an excellent safety profile in human studies at commonly used amounts. Mild digestive upset is uncommon. Discontinue if you experience any adverse reaction.


Evidence Snapshot

  • Sleep: supports healthy sleep quality when used in the evening.
  • Collagen: major structural amino acid for skin, joints & bones.
  • Detox: required for glutathione synthesis and bile‑acid conjugation.
  • Metabolic: helps maintain healthy post‑meal steadiness and methylation balance.


Glycine — Selected Scientific References (20)

  1. Inagawa K., et al. Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep & Biological Rhythms. 2006. https://doi.org/10.1111/j.1479-8425.2006.00193.x
  2. Yamadera W., et al. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep & Biological Rhythms. 2007. https://doi.org/10.1111/j.1479-8425.2007.00262.x
  3. Bannai M., et al. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Frontiers in Neurology. 2012. PMCID: PMC3328957
  4. Kawai N., et al. The sleep-promoting & hypothermic effects of glycine via the suprachiasmatic nucleus. Neuropsychopharmacology. 2015. Link
  5. Lizzo G., et al. Randomized controlled clinical trial: Glycine & N-acetylcysteine (GlyNAC) and glutathione redox status in older adults. Frontiers in Aging. 2022;3:852569. PMCID: PMC9261343
  6. Kumar P., et al. Glycine & N-acetylcysteine (GlyNAC) supplementation in aging humans: randomized placebo-controlled trial. Clinical and Translational Medicine. 2021. Link
  7. Sekhar R.V., et al. GlyNAC supplementation improves glutathione deficiency & oxidative stress in older humans. Journal of Nutrition. 2022. Link
  8. Adeva-Andany M.M., et al. Insulin resistance & glycine metabolism in humans: clinical and mechanistic links. Annals of Hepatology. 2018. PMID: 29094215
  9. Gannon M.C., et al. The metabolic response to ingested glycine in humans. American Journal of Clinical Nutrition. 2002. PMID: 12450897
  10. Rom O., et al. Glycine-based treatment ameliorates NAFLD by stimulating fatty-acid oxidation & glutathione synthesis. Science Translational Medicine. 2020. PMID: 33268508
  11. Zhao J., et al. Genetically predicted plasma amino acids & MAFLD risk: Mendelian randomization. BMC Medicine. 2023. Link
  12. de Paz-Lugo P., et al. High glycine concentration increases collagen synthesis by articular chondrocytes. Regenerative Therapy. 2018. PMCID: PMC6153947
  13. de Paz-Lugo P., et al. Control analysis of collagen synthesis by glycine, proline & lysine. Biochimica et Biophysica Acta – General Subjects. 2023. Link
  14. Genton L., et al. Glycine increases fat-free mass in malnourished haemodialysis patients: randomized double-blind crossover trial. Journal of Cachexia, Sarcopenia & Muscle. 2021. Link · PMCID: PMC8718019
  15. Vargas M.H., et al. Effect of oral glycine in cystic fibrosis: clinical, spirometric & inflammatory outcomes. BMC Pulmonary Medicine. 2017. Link
  16. Gan Z., et al. Glycinergic signaling in macrophages & implications for inflammatory disease. Frontiers in Immunology. 2021. PMCID: PMC8523992
  17. Chen I., et al. Physiology of bile acids: conjugation with glycine or taurine (overview). StatPearls. 2023. Link
  18. Di Ciaula A., et al. Bile acid physiology: synthesis, glycine/taurine conjugation & function. Annals of Hepatology. 2017. Link
  19. Hofmann A.F. The continuing importance of bile acids in liver & intestinal disease (conjugation with glycine/taurine). JAMA Internal Medicine. 1999. Link
  20. Gowda G.A.N., et al. Bile acid conjugation in human bile is not random: glycine/taurine patterns. Journal of Lipid Research. 2009. PMCID: PMC5459358

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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These statements have not been evaluated by the Food and Drug Administration. No product mentioned herein is intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before making any lifestyle change, including trying a new product or food.

The information on this website is intended as a sharing of knowledge and information from the research and experience of the Healthy-Living.Org staff and contributors. It is not intended to replace a one-on-one relationship with a qualified health care professional and it is not intended as medical advice. You should not use the information on this site for diagnosis or treatment of any health problem or for modification of any medication regimen. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before starting or discontinuing any medication, or if you suspect you have a health problem. You should keep in mind that cited references to ongoing nutritional scientific study are most likely not accepted by the FDA as conclusive. These references and mentions of benefits experienced by others are disavowed as product claims and are only included for educational value and as starting points for your own research. No food or supplement can be considered safe for all individuals. What may benefit 999,999 of a million people may harm you. Therefore, no one can take responsibility for your health except you in concert with your trusted health professional.