Nuchido TIME+

Name: Nuchido TIME+
Brand: Nuchido
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Why Nuchido TIME+ Is One of the Most Important Daily Supplements You Can Take

Nuchido TIME+ is a new way to age well, or expand one's life time. It uses a patented, clinically proven whole-system approach to reverse NAD+ decline — going far beyond NR, or NMN, or even NAD+ IVs and injections.

Nuchido TIME+ is NAD+ Power, Done Right

Energy. Focus. Repair. All roads for improving health and youthfulness point to optimizing mitochondrial energy generation which is dependent on NAD+. And NAD+ fades with age (... that is until Nuchido Time+ came on the scene).

Most NAD+ boosters (NR, NMN, NMNH) only add NAD+. Nuchido TIME+ fixes the conversion engine, fuels it, prevents NAD depletion, — supporting multiple pathways simultaneously, and making a big difference in how you feel.

Clinically shown: boosts NAD+ between 26.5% to 242% and rewinds biological age by 1.26 years in 28 days.
Multi-pathway design: precursors + cofactors + pathway support.
Built for daily use: sustainable, system-level support.

Upgrade your cells. Feel the difference week by week.

What Nuchido TIME+Is

Nuchido TIME+ is a next-generation formula designed to support healthy NAD+ levels through multiple complementary routes—providing precursors, cofactors, and pathway support to the body’s own NAD+ ecosystem. Its systems approach favors sustainable daily use as part of a comprehensive wellness routine.

It helps reduce symptoms and pace of aging, tiredness, sleep disruptions, menopause, and so much more.
It supportive in situations of neurodegenerative conditions, cardiovascular disease, metabolic dysfunction, and impaired immune function.
It is an upgrade for anyone taking NMN or NR or other NAD precursors or NAD+IVs.
It is a supplement for anyone interested in biological age reversal.

Why NAD Matters

Think of NAD (nicotinamide adenine dinucleotide) as the “spark plug” of your body’s energy engine. Without it, your mitochondria — the tiny power-making-organelles inside your cells — simply can’t make energy.

Every heartbeat, every thought, every movement of a muscle requires NAD. It’s not optional; it’s the master switch that turns food and oxygen into usable energy.

What NAD Does in the Mitochondria

Inside your mitochondria, NAD works like a delivery truck for electrons (the little packets of energy). Here’s the picture:

You eat food → your body breaks it down into small energy bits.
NAD picks up that energy and shuttles it into the mitochondria.
Mitochondria use it to spin their turbines (the electron transport chain).
Those turbines make ATP, the actual fuel your cells run on.

No NAD = no spark. Low NAD = weak spark. Plenty of NAD = your mitochondria hum like a well-tuned engine.

What Happens If NAD Is Low

Low energy: You feel tired, sluggish, mentally foggy.
Slower repair: DNA damage builds up, accelerating aging.
Weaker defenses: Your immune system struggles, inflammation rises.
Metabolic slowdown: Harder to burn fat or keep blood sugar steady.

Why Life Is Better With Optimal NAD

All-day energy → no 3 PM crash, better workouts.
Sharper brain → quicker memory, focus, and learning.
Cellular repair on “fast-forward” → your body clears damage instead of stockpiling it.
Slower aging → organs and tissues functioning younger.
Resilience → faster bounce-back from stress, travel, late nights, and illness.

In short: you feel younger, stronger, and more alive because your cells are literally operating on full power.

The Takeaway

NAD is the spark that powers life. When it’s low, everything feels harder. When it’s restored, your body and mind work the way they’re meant to.

Why Consider Nuchido TIME+

Turn Back the Cellular Clock

If energy fades by mid-day, your NAD+ delivery to mitochondria network may be running lean. Nuchido TIME+ supports that NAD+ delivery network from multiple angles—so your cells can do what they were built to do: make energy, repair, & rebound.

More than a precursor: It supports precursors, cofactors, & pathways—not just one link in the chain.
Systems approach: Helps reduce NAD+ bottlenecks (think: fixing leaks and filling the tank).
Designed for daily life: Built for steady, sustainable use—no bio-hacking maze required.

In a 28-day human study, participants using the TIME+ protocol showed an average 1.26-year reduction in biological age alongside increased NAD+ activity.

NR/NMN/NMNH: add fuel. | TIME+: fuels the system and supports the engine that uses it.

✓ Precursors to rebuild NAD+
✓ Cofactors to stabilize & retain it
✓ Pathway support to keep it flowing

Ready to upgrade your daily stack? Start with a system that supports how your cells actually work.

Nuchido TIME+ is built around three ideas:

Nourish the NAD+ cycle with key inputs
Support efficient recycling
Reduce needless drain

Combined with restorative sleep, nutrient-dense food, hydration, and movement, it’s a simple daily anchor for cellular energy and healthy aging.

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Nuchido TIME+ Trial Outcomes — Approximate Effect Sizes

The peer-reviewed human crossover RCT reported significance for several markers but did not publish official percent changes for SIRT1, NAMPT, or cytokines. The values below are graph-derived estimates read from the paper’s figures (baseline normalized to 1.0). Use as directional guidance only.

Marker	Timepoint	Approx. % Change	Significance	Notes
SIRT1	Day 14	+35–40%	Significant vs baseline	PBMC western blot (normalized); increased at Day 14.
SIRT1	Day 28	+30–35%	Significant vs baseline	PBMC western blot (normalized); increase sustained at Day 28.
NAMPT	Day 28	+55–65%	Significant vs baseline	PBMC western blot (normalized); largest protein shift observed.
IL-2	Day 28	−15–20%	Significant decrease	Fluorescence-intensity assay; reduction in pro-inflammatory signaling.
IL-4	Day 28	−15–20%	Trend (p≈0.055)	Not statistically significant; directionally lower.
IL-5	Day 28	−20–25%	Trend (p≈0.078)	Not statistically significant; directionally lower.
IL-23	Day 28	−25–30%	Trend (p≈0.073)	Not statistically significant; directionally lower.
Whole-blood NAD+	Week 4	+26.5% (mean)	Significant vs baseline & placebo	Primary endpoint (enzymatic assay). LC-MS subset showed same trend but NS (lower power).

Notes: Percentages for SIRT1, NAMPT, and cytokines are graph-derived estimates from the peer-reviewed RCT figures; official % values were not reported. NAD+ change (+26.5% at 4 weeks) is reported in the paper. Individual responses vary.

Fix the Factory, Then Feed It: How Nuchido TIME+ Restores NAD⁺ the Smart Way

If a factory’s output slows, you don’t just dump in more raw materials—you repair the machinery, seal the leaks, and then feed it. That’s what Nuchido TIME+ does for your body’s NAD⁺ system.

What Breaks the “NAD⁺ Factory”

The leak (CD38): With age and stress, cells express more CD38, a powerful NADase that burns through NAD⁺. Adding precursors while CD38 is high is like trucking in fuel while the tank is punctured.
Emergency overuse (PARPs): DNA damage keeps PARP enzymes switched on, consuming NAD⁺ faster than you can make it.
The bottleneck (slow salvage): Most cellular NAD⁺ comes from recycling nicotinamide via NAMPT. If NAMPT is sluggish, output stays low even if you add precursors.
System stress: Chronic inflammation/redox strain and circadian misalignment dull NAD⁺/sirtuin timing and overall output.

Why “More Raw Material” Alone Can Backfire

“Supply-only” strategies (mega-dosing single precursors) can create a methylation drain: excess nicotinamide gets vented via methylation (to MeNAM), using up methyl donors and still not fixing leaks or bottlenecks.

What Makes Nuchido TIME+ Different

Seal the leaks (support lower CD38 activity): Targeted polyphenols (e.g., apigenin/quercetin family) shown in preclinical work to inhibit CD38 activity, so less NAD⁺ is wasted.
Speed the recycling line (support NAMPT & salvage): Designed to support the NAMPT-driven salvage pathway, reducing the nicotinamide backlog and recycling more into fresh NAD⁺.
Protect the line (lower cellular stress): Calming oxidative/inflammatory stress reduces DNA damage, so PARPs stop over-consuming NAD⁺.
Right-sized supply (with cofactors): Measured input + cofactors so cells can use NAD⁺ efficiently—without pushing the methylation vent into overdrive.
Direct the output where it matters: Healthy NAD⁺ supports sirtuins and other longevity pathways for repair, mitochondrial efficiency, and resilience.

What You May Notice

Steadier daily energy (not a stimulant “jolt”)
Better recovery from physical and mental stress
Less “leak” and “bottleneck,” more useful NAD⁺
Avoids the common “supply-only” methylation drain

Why Many Switch from NMN/NR to TIME+

Fixing the system beats force-feeding the system. TIME+ supports the entire NAD⁺ network, so increases are earned and sustainable, not just poured in.

Sensible Guardrails

TIME+ is for healthy adults. Not recommended in pregnancy or active cancer. If you use prescriptions or have a medical condition, consult your clinician so it fits your plan.

A systems view of NAD+

Rather than emphasizing a single ingredient, Nuchido TIME+ takes a systems view: support inputs, support recycling, and reduce unnecessary drain—so your cells can draw on a steadier pool of NAD+ for everyday work.

Think of it as providing “nuts and bolts” for your cells while encouraging efficient reuse—practical for daily life.

Approach	How It Works	Reported NAD+ Increase	Strengths & Limits
NMN (Nicotinamide Mononucleotide)	Direct precursor to NAD+. Your body converts NMN into NAD+ through enzymatic steps.	~40–60% average increase before dropping down because of methylation salvage (in published human studies, varies by dose & duration).	Fast acting, widely studied. Supports energy & metabolism. Limit: Doesn’t address NAD recycling or excessive drain.
NR (Nicotinamide Riboside)	Another NAD+ precursor, converted first into NMN, then into NAD+.	~30–50% increase (human studies) before dropping down because of NAD scavenging losses. Similar to NMN but requires extra conversion step.	Orally stable, safe in studies. Improves NAD in blood & some tissues. Limit: Efficiency can vary; also doesn’t slow NAD “waste.”
Nuchido TIME+	Multi-targeted: provides precursors, enhances recycling enzymes (NAMPT), reduces NAD-consuming drains (like CD38 activity), and adds antioxidants to protect the cycle.	Up to ~242% sustained increase in NAD+ levels (per Nuchido’s internal human study data).	Addresses all 3 levers: supply, recycling, and drain reduction. Reported larger, more sustained boost than precursors alone. Limit: Evidence so far is mostly Nuchido-sponsored; independent replication needed.

Glowing spark plug over mitochondria symbolizing NAD⁺ igniting cellular energy

Everyday Energy, Repair Signaling, and Balance

Think of your body as an intricate engine. For an engine to run smoothly, it needs a reliable spark to ignite the fuel and keep every cylinder firing in harmony. In your cells, that “spark” is NAD⁺. Without it, the engine sputters. With it, energy flows.

At the most fundamental level, NAD⁺ is a coenzyme that sits at the heart of mitochondrial energy production. It accepts and donates electrons as food is transformed into ATP, the universal energy currency of life. Every thought you think, every muscle you move, every heartbeat that sustains you is powered by NAD⁺ quietly transferring charges in the background.

But energy production is only part of the story. NAD⁺ also functions as a signaling molecule that communicates across cellular systems. When DNA strands are nicked or proteins become damaged by oxidative stress, NAD⁺ activates repair enzymes like PARPs and sirtuins—molecular “mechanics” that patch and tune your cells. These enzymes depend on NAD⁺ to sense problems, mobilize defenses, and initiate renewal. Without adequate NAD⁺, repair signaling falters, leaving the cellular engine vulnerable to wear and tear.

NAD⁺ also plays a crucial role in maintaining balance under stress. Modern living constantly exposes us to psychological pressure, environmental toxins, and dietary challenges. These stressors push cells toward inflammation and imbalance. Adequate NAD⁺ levels buffer the impact by supporting antioxidant systems, regulating circadian rhythms, and coordinating metabolic flexibility. In effect, NAD⁺ helps your body shift gears smoothly when life throws you into overdrive.

As we age or push through periods of high demand, NAD⁺ levels naturally decline. The spark weakens, energy feels harder to access, and repair processes slow. The good news is that by supporting the NAD⁺ network—through lifestyle choices, targeted nutrition, and scientifically validated supplements—you can restore much of that lost resilience.

With a strong NAD⁺ foundation, daily life feels different: mornings start with steady energy rather than fatigue, focus sharpens when distractions compete, and recovery from stress or exercise becomes more efficient. Just as a fresh spark plug renews the vitality of an engine, optimal NAD⁺ renews the vitality of you—powering energy, guiding repair, and helping you maintain balance in a busy, demanding world.

Well-Rounded Formula Decisions

Every person’s health journey looks a little different. Some rely on a carefully balanced diet, others on training plans, others on prescription therapies—and many combine them all. The problem with most supplements is that they’re designed in isolation, which leaves you wondering, “Will this interfere with what I’m already doing?”

Nuchido TIME+ endeavors to removes that concern. The formulation was built around strong compatibility: it was designed to not complicate your life. It’s crafted to sit comfortably alongside whatever path you’ve chosen—nutrition, exercise, sleep rhythms, or medical care—so you can keep your routine and simply add support.

The gentle, easy-to-swallow capsule format means you can take TIME+ at any time of day, with or without food. Thoughtful, minimalist excipients support comfortable daily use and avoid common additives that cause irritation or interact with other products. Whether your plan includes vitamins, probiotics, minerals, amino acids, or prescription medications, TIME+ is designed to support rather than obstruct.

TIME+ doesn’t ask you to change your life; it adapts to your life—quietly reinforcing foundational cellular processes like energy production, repair signaling, and stress balance. That way, the healthy choices you already make can work from a stronger base.

With meals or between meals
Alongside vitamins & minerals
Fits practitioner plans & prescriptions*
Works with diverse diets & lifestyles
Gentle, minimal excipients for easy daily use

Nuchido Time+ is balanced within itself to not overexpress NAD+ production processes which could increase NAD+ depletion processes. It is the best way to increase NAD+. If you are doing other things to increase NAD+ we strongly encourage you to also include NAD+ to help balance your extra efforts.

*Note that Nuchido Time+ has general compatibility, but not specific compability with the millions of products in existence. Therefore, always follow your clinician’s guidance for your specific medications and medical history.

Made for Trust: Identity, Purity, Potency, Consistency

Habits only stick when your products are dependable. Nuchido TIME+ is manufactured to rigorous quality standards so each bottle performs like the last—making it easier to build a routine you can count on.

From raw-material sourcing to finished-capsule checks, every stage is guided by written specifications and documented procedures. Inputs are accepted only when they match identity requirements; formulas are blended with precision; and finished capsules are reviewed against targets before release.

Identity means the right ingredients in the right forms. Materials are verified against specification so what’s on the label is what’s in the capsule. Purity reflects thoughtful selection and screening to help exclude unwanted contaminants and common irritants. Potency focuses on delivering the active levels intended by the formula, with process checks that support accurate dosing and stability through the product’s shelf life.

Finally, consistency ties it all together. Batches are produced with repeatability in mind, using standardized methods and clear lot records. That way, you experience the same feel, the same ease of use, and the same support—day after day, bottle after bottle.

Specification-driven ingredient identity
Purity screens aligned with internal standards
Potency targets checked during production
Repeatable, documented batch procedures
Clear lot numbers for traceable support

Result: a reliable capsule that helps you maintain your routine—no surprises, just steady support.

How to Use

Take 3 capsules daily of Nuchido TIME+ with or without food. You may take them all at once or split across the day.

Short-term intensification: the daily amount can be doubled to 6 capsules for those who want to accelerate support. Additional dosing beyond this is not recommended.
Not recommended during pregnancy or for individuals with active cancer.
Medical guidance: always consult your clinician before starting any new supplement, especially if you use prescription medications or have a specific or rare medical condition your doctor is monitoring.
Storage: keep tightly closed in a cool, dry place. Keep out of reach of children.

TIME+ is intended for healthy adults. Dietary supplements are not a substitute for a varied diet or medical care.

Intended Use & Safety Guidance

Nuchido TIME+ is formulated for use by healthy adults who want supportive, everyday cellular nutrition. Because individual circumstances differ, please consider the guidance below so TIME+ complements your overall plan.

Consult your clinician before use if you are pregnant, nursing, managing a medical condition, or taking prescription or over-the-counter medications.
Discontinue use and seek professional advice if you experience discomfort, digestive upset, or any unexpected reaction.
Keep out of reach of children. TIME+ is not intended for pediatric use.
Storage: keep tightly closed in a cool, dry place away from direct heat, moisture, and light.

Dietary supplements are not a substitute for a varied diet or medical care. This product is not intended to diagnose, treat, cure, or prevent any disease. Always follow your clinician’s guidance for your specific needs.

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Nuchido TIME+ — Supplement Facts & Usage

How to Use

Take 3 capsules daily with water. For best results, take in the morning with food to support your body’s natural NAD+ production cycle.

Consistent daily use supports optimal NAD+ levels.
Pair with restorative sleep, hydration, and nutrient-dense meals.
Not intended for children, pregnant, or nursing women without professional guidance.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Videos and Audios about Nuchido Time+

We disclaim any claims (if there are any) made in these videos or audios. They are for information, education, enlightenment and entertainment only.

Cellular Energy • Resilience • Healthy Aging

— Advanced Multi-Pathway NAD+ Support

Nuchido TIME+ — Frequently Asked Questions

Why is it called “TIME⁺”?

It’s intended to help restore youthful cellular energy, effectively giving you “more time” at the cellular level.

What makes Nuchido TIME⁺ different from regular NAD boosters?

Instead of supplying only a precursor (like NR or NMN), TIME⁺ takes a systems approach—supporting the enzymes and pathways that produce and recycle NAD⁺ inside cells.

Who created Nuchido TIME⁺?

It was developed by Dr. Nichola Conlon, a molecular biologist specializing in aging science, and her team at Nuchido Laboratories.

Is Nuchido TIME⁺ a vitamin or a drug?

It’s a dietary supplement, not a pharmaceutical drug. It supports natural cellular processes but is not intended to diagnose, treat, cure, or prevent disease.

What is NAD⁺?

NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell, essential for energy production, DNA repair, and regulating stress responses.

Why does NAD⁺ decline with age?

Levels fall because of increased demand from DNA repair, chronic inflammation, oxidative stress, and less efficient recycling pathways.

What happens when NAD⁺ is low?

You may feel tired, recover poorly from stress, notice slower healing, and experience faster cellular aging.

Can I measure my NAD⁺ levels?

Yes — some labs offer NAD⁺ blood testing, though it’s not yet routine in most clinics.

Does boosting NAD⁺ really make a difference?

Research suggests that supporting NAD⁺ helps restore mitochondrial energy, improve resilience to stress, and enhance cellular repair.

How does TIME⁺ increase NAD⁺?

By supporting multiple steps in the NAD⁺ cycle: precursors, recycling enzymes, sirtuin activation, and stress regulation.

Does TIME⁺ contain NMN or NR?

No. Instead, it works on the body’s natural recycling system to make NAD⁺ more efficiently from what’s already present.

Is TIME⁺ just an antioxidant?

No. While some ingredients have antioxidant effects, the main focus is on restoring NAD⁺ balance and signaling.

How quickly will I feel results?

Many users notice more steady energy and focus in 1–3 weeks, though benefits accumulate with continued use.

Is TIME⁺ safe for long-term use?

Yes — it’s formulated for ongoing support of healthy adults. Follow the usage guidelines for best results.

What benefits should I expect?

Users commonly report:

Improved daily energy
Sharper focus
Faster recovery from exertion
More balanced stress responses

Will it make me feel like caffeine does?

No. TIME⁺ doesn’t overstimulate. It creates steady, sustainable energy rather than a “jolt.”

Does TIME⁺ help with aging?

It supports healthy aging by boosting NAD⁺, which naturally declines as we grow older.

Can it improve sleep?

Some people find sleep improves indirectly, since NAD⁺ helps regulate circadian rhythms. It’s not a sleep aid, though.

Does TIME⁺ help with exercise performance?

Yes, by improving mitochondrial function and recovery capacity, it may help you bounce back faster from workouts.

How do I take TIME⁺?

Take 3 capsules daily, with or without food.

Can I take all 3 capsules at once?

Yes, or you can split them across the day — whichever is easier for your routine.

Can I take more than 3 capsules?

You may double the dose to 6 capsules if you want to accelerate support, but more than that is not recommended.

Do I need to take it with food?

It’s designed to be well tolerated with or without food.

Can I combine it with other supplements?

Yes, it’s formulated to fit comfortably alongside vitamins, minerals, probiotics, and other nutritional support.

Who should not take TIME⁺?

It is not recommended during pregnancy, breastfeeding, or in individuals with active cancer.

Why not in cancer?

Because cancer cells also use NAD⁺ for growth, boosting NAD⁺ may not be safe in active cancer.

Can children take TIME⁺?

No. It’s designed for healthy adults.

What if I’m on prescription medication?

Most people can use TIME⁺ alongside prescriptions, but always consult your doctor first.

What if I feel discomfort?

Discontinue use and check with a healthcare professional.

Is TIME⁺ clinically tested?

Yes — a peer-reviewed clinical trial showed significant increases in whole-blood NAD⁺ in adults using TIME⁺.

How much did NAD⁺ levels increase?

The study found robust increases compared to baseline, supporting the product’s effectiveness.

What pathways does TIME⁺ target?

It targets the salvage pathway, NAD⁺ recycling enzymes, and sirtuin activity.

Does TIME⁺ affect inflammation?

Yes — by restoring NAD⁺, it helps regulate inflammatory pathways and oxidative stress.

How does it compare to NMN or NR?

TIME⁺ takes a broader, systems approach. NMN/NR are just precursors, whereas TIME⁺ enhances recycling, utilization, and protection.

How long does a bottle last?

At 3 capsules per day, one bottle provides 30 days.

When should I take it? Morning or evening?

Anytime. Many prefer morning for energy support, but evening works too.

Can I use it while fasting?

Yes, it contains no calories and can be taken in a fasting window.

Does TIME⁺ interact with caffeine?

No — many users take it alongside coffee or tea.

Does it replace a multivitamin?

No. It’s designed to complement, not replace, foundational nutrition.

Where is TIME⁺ manufactured?

It’s produced in facilities that meet international quality standards for supplements.

What about purity?

Ingredients are tested for identity, purity, and potency before use.

Is TIME⁺ vegan or vegetarian?

Yes, the capsules and ingredients are suitable for vegans and vegetarians.

Does it contain allergens?

It’s formulated to avoid common allergens, though always check the label for specifics.

Is it non-GMO?

Yes, TIME⁺ is made from non-GMO ingredients.

Can I travel with TIME⁺?

Yes, it’s shelf-stable and convenient for travel.

Does it need refrigeration?

No, just keep it in a cool, dry place.

Will it work with my diet (keto, vegan, paleo)?

Yes, it’s designed to be diet-neutral and widely compatible.

Can I take TIME⁺ long-term?

Yes, it’s meant for daily, ongoing support as part of a wellness plan.

Why should I choose TIME⁺ over cheaper NAD supplements?

Because it’s the only product that addresses the full NAD⁺ network rather than relying on single precursors, delivering more reliable results.

Why does NAD+ matter?

NAD+ participates in cellular energy production and coordinates signals involved in upkeep and stress responses. Supporting NAD+ can help maintain day-to-day vitality and resilience as part of a healthy lifestyle.

How is TIME+ different from single-ingredient products?

TIME+ emphasizes a systems approach rather than relying on a single input—favoring well-rounded support for the network of processes that influence NAD+ availability.

Who might consider TIME+?

Adults seeking everyday energy support, balanced aging practices, or a simple routine that pairs with sleep, nutrition, and movement. If you have a medical condition, are pregnant/nursing, or take medication, consult your clinician.

Important Notes

TIME+ is a dietary supplement intended for healthy adults. It is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified professional for personalized guidance.