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RiSoTriene - Scientific Research

A huge amount of research has been compiled regarding the benefits of stabilized rice bran. Here is just a sampling:

  1. Itaya, K., J. Kiyonaga, and M. Ishikawa. 1976. “Studies of Gamma-Oryzanol (2). The Antiulcerogenic Action.” Nippon Yakurigaku Zasshi 72(8): 1001-1011.
  2. Itaya, K. and J. Kiyonaga. 1976. “Studies of Gamma-Oryzanol (1). Effects on Stress- Induced Ulcer.” Nippon Yakurigaku Zasshi 72(4): 475-481.
  3. Hata, A., S. Koga, H. Shigematsu, S. Kato, et al. 1981. “Study on Effects of Gamma-Oryzanol on Hyperlipemia: – Multicenter Cooperative Pilot Study for Dosage Finding. Geriat. Med. 19: 1813-1840.
  4. Ieiri, T., Kase, N., Hashigami, Y., Nakumura, T., Shimoda, S., (1982) “Effect of gamma oryzanol on the hypothalamo-pituitary axis in the rat.” NipponNaibunpi Gokkai Zasshi, 58(10): 1350-6.
  5. Ohkawa, T., Ebisuno, S., Kitagava, M., Morimoto, S., Miazaki, Y., and Yasukava, S., (1984): “Rice bran treatment for patients with hypercalciuric stones: Experimental and Clinical studies.” The Journal of Urology, 132: 1140-1145.
  6. Ichimaru, Y., M. Moriyama, M. Ichimaru, and Y. Gomita. 1984. “Effects of Gamma-Oryzanol on Gastric Lesions and Small Intestinal Propulsive Activity in Mice.” Nippon Yakurigaku Zasshi 84(6): 537-542.
  7. Saunders, R.M (1986) “Rice bran composition and potential food uses.” Food Rev. Int.8: 455-498.
  8. Raghuram, T.C., U.B. Rao, and C. Rukmini. 1989. “Studies on Hypolipidemic Effects of Dietary Rice Bran Oil in Human Subjects.” Nutr. Rep. Intl. 39: 889.
  9. Nicolosi, R.J. 1991. “Health Benefits Attributed to Derivatives of Rice Bran.” Cereal Foods World 36(8): 720.
    Nicolosi, R.J., L.M. Ausman, and D.M. Hegsted. 1991. “Rice Bran Oil Lowers Serum Total and Low Density Lipoprotein Cholesterol and Apo B Levels in Nonhuman Primates”. Atherosclerosis 88: 133-142.
  10. Qureshi, A.A., N. Qureshi, J.O. Hasler-Rapacz, F.E. Weber, V. Chaudhary, T.D. Crenshaw, A. Gapor, A.S.H Ong, Y.H. Chong, D. Peterson and J. Rapacz. 1991. “Dietary Tocotrienols Reduce Concentrations of Plasma Cholesterol, Apolipoprotein B. Thromboxane B2, and Platelet Factor 4 in Pigs with Inherited Hyperlipidemia.” Am. J. Clin. Nutr. 53: 1042S-1046S.
  11. Quershi, A.A., N. Quershi, J.J.K. Wright, Z. Shen, A. Kramer, A. Gapor, Y.H. Chong, G. DeWitt, A.S.H. Ong, D.M. Peterson, and B.A. Bradlow. 1991. “Lowering of Serum Cholesterol in Hypercholesterolemic Humans by Tocotrienols.” Am. J. Clin. Nutr. 53: 1021S-1026.
  12. Hirose, M., K. Ozaki, K. Takaba, L. Fukushima, T. Shirai, and N. Ito. 1991. “Modifying Effects of the Naturally Occurring Antioxidants g-Oryzanol, Phytic Acid, Tannic Acid, and n-Tritriacontane-16, 18-Dione in a Rat Wide-Spectrum Organ Carcinogenesis Model.” Carcinogenesis 12(10): 1917-1921.
  13. Hiramitsu, T. and D. Armstrong. 1991. “Preventive Effect of Antioxidants on Lipid Peroxidation in the Retina.” Ophthalmic Res. 23: 196-203.
  14. Qureshi, A.A., Qureshi, N., Hasler-Rapacz, J.O., (1991) “Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, thromboxane B2 and platelet factor 4 in pigs with inherited hyperlipidemias.” Am. J. Clin. Nutr. 53: 1021S.
  15. Nicolosi, R.J., Ausman, L.M., and Hegstead, M (1991) “Rice bran oil lowers serum and LDL lipoprotein cholesterol and apo B levels in non-human primates.” Atherosclerosis. 88(2-3) 133-142.
  16. Rukmini, C., and Raghuram, T.C., (1991) “Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil: A review.” J. Amer. Coll. Nutrition. 10: 366-375.
  17. Tomeo, A.C., Geller, M., Watkins, T.R., (1995) “Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stress.” Lipids, 30: 1179.
  18. Kahlon, T.S., F.I. Chow, M.M. Chiu, C.A. Hudson and R.N. Sayre. 1996.
  19. “Cholesterol-Lowering by Rice Bran and Rice Bran Oil Unsaponifiable Matter in Hamsters.” Cereal Chemistry 73(1): 69-74.
  20. Bouic, P. J. D., Etsbeth, S., Liebenberg, R.W., Albrecht, C. F, Pegel, G., Van Jaarsveld, P.P., (1996) “Beta-sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: Implication for their use as an immunomodulatory vitamin combination.” International J. Immunopharmacology, 18(12): 693-700.
  21. Kahlon, T.S., and F.I. Chow. 1997. “Hypocholesterolemic Effects of Oat, Rice, and Barley Dietary Fibers and Fractions.” Cereal Foods World 42(2): 86-92.
  22. Qureshi, A.A., Bradlow, B. A., Salser, W. A., Brace, L. D., (1997) “Novel tocotrienols of rice bran modulate cardiovascular disease risk parameters of hypercholesterolemic humans.” J. Nutrition Biochem 8: 1-9.
    Rong, N., L.M. Ausman, and R.J. Nicolosi. 1997. “Oryzanol Decreases Cholesterol Absorption and Aortic Fatty Steaks in Hamsters.” Lipids 32(3): 303-309.
  23. Fry, A.C., E. Bonner, D.L. Lewis, R.L. Johnson, M.H. Stone, and W.J. Kraemer. 1997. “The Effects of Gamma-Oryzanol Supplementation During Resistance Exercise Training.” International Journal of Sport Nutrition 7(4): 318-329.
  24. Sugano, M., and Tsuji, E., (1997) “Rice bran oil and cholesterol metabolism.” Jl of Nutrition 127(3): 521S-524S.
  25. Nesaretnam, K., R. Stephen, R. Dils, and P. Darbre. 1998. “Tocotrienols Inhibit the Growth of Human Breast Cancer Cells Irrespective of Estrogen Receptor Status.” Lipids 33: 461-469.
  26. Kim, J.S., J.S. Godber, J.M. King, W. Prinyawiwatkul, and H.Y. Chung. 2000. “Vitamin E Vitamers and g-Oryzanol from Rice Bran Inhibit the Formation of 7-Ketocholesterol in Aqueous Dispersion System.” (51E-1). Book of Abstracts: IFT Annual Meeting, Dallas, Texas. June 10-14.
  27. Cheruvanky, R., McPeak, P., Cherukuri, R.S, and Lynch, I., (2000)“Method for treating hypercholesterolemia, hyperlipidemia and atherosclerosis.” US Patent 6,126,943 and US Patent 6,350,473 B1.
  28. Xu Z, Hua, N., Godber, J. S., (2001) “Antioxidant activity of tocopherols, tocotrienols, and gamma oryzanol components from rice bran against cholesterol oxidation accelerated by 2,21-azobis(2-methylpropionamideine) dihydrochloride.” J. Agric. Food. Chem, 49(4):2077-81.
  29. Qureshi, A.A., Sami, S.A., and Khan, F.A., (2002)“Effects of stabilized rice bran, its soluble and fiber fractions on blood glucose levels and serum lipid parameters in humans with diabetes mellitus Type1 and Type11." J. Nutritional Biochem 13:175-187.
  30. Qureshi, A.A., Sami SA, Salser WA, Khan FA, (2002) “Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF(25)) of rice bran in hypercholesterolemic humans.” Atherosclerosis 2002; 161: 199-207.


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