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Sulforaphane Bottle

Sulforaphane - Extracted and Activated from Broccoli Seeds

broccoli seeds - source of sulforaphane

Clean, Potent, Bioactive: 1 Capsule = the Sulforaphane of 4.5 Cups of Broccoli

“Upregulate your body’s own defense systems.”

Sulforaphane is a broccoli-sprout compound that activates Nrf2—your cells’ master switch for antioxidant & detox responses.

What This Sulforaphane Is

A concentrated broccoli seed extract — providing active, stable sulforaphane at a dosage of 10 mg per capsule, or 20 grams per 2 capsule serving. It starts as sulforaphane glucosinolate (inactive), but it is activated during the extraction process by the myrosinase enzyme. 

  • One serving provides the equivalent sulforaphane of 9 cups (1.8 pounds) of raw broccoli or equivalent to 19 pounds (95 cups) of cooked broccoli.
  • Sulforaphane supports Nrf2 activation & the body’s phase II detox enzymes (e.g., glutathione, NAD(P)H:Quinone Oxidoreductase 1) — with the bottom line of turning on the body's in-house defense system (fast) and keeping it turned on (longer term)
  • Formulated for consistent yield per serving (not just “broccoli powder”) or inactive sulforaphane.
  • Manufactured for low heat exposure to protect its potency and activity.

Benefit from the power of Sulforaphane

⸺ Promote Nrf-2

Sulforaphane works in two ways; it promotes the anti-inflammatory pathway known as Nrf2 and blocks the pro-inflammatory pathway known as Nf-kB.

⸺ Encourage Detoxification

Sulforaphane works in all three phases of detox. It is the most potent known natural Phase 2 detoxifier.

⸺ Protect + Restore Brain Function

Sulforaphane travels to the brain to support the survival of existing neurons and encourage the formation of new ones. Low Nrf2 functioning is linked to neurodegenerative diseases like Parkinson's and Alzheimer's.

Why Use Sulforaphane Daily

Daily sulforaphane helps your body defend and repair: it switches on intrinsic antioxidant systems, supports normal inflammatory balance, enhances cellular cleanup (proteostasis & autophagy), and promotes healthy detoxification of everyday pollutants.

Four practical benefits people take it for:

  1. Cellular Defense supports glutathione recycling & phase II enzymes to help neutralize oxidative stress from life’s exposures.
  2. Detox Support promotes the body’s natural clearance of certain airborne & dietary compounds.
  3. Skin Support supports skin health by helping protect against free radicals and toxins accmulating in skin.
  4. Brain & Nerve Support supports neuroprotective pathways and healthy synaptic signaling.
  5. Metabolic Resilience helps maintain a healthy inflammatory response that underpins cardiovascular, liver, and metabolic well-being.

Sulforaphane: Keep Your Cells Younger, Longer

Sulforaphane is a dietary signal that tells your cells to switch on their own protection systems. Instead of acting like a one-and-done antioxidant, it activates the Nrf2 pathway—the master regulator of your body’s internal defenses—helping maintain robust glutathione recycling, phase II detoxification, and balanced inflammatory signaling. The result is wider-ranging resilience: cells cope better with daily stressors from pollutants, poor sleep, high workloads, and metabolic strain.

  • Antioxidant & detox defense: Encourages your cells to make more of their own protective enzymes (e.g., NQO1, HO-1, GSTs), supporting glutathione status and the clearance of everyday toxins.
  • Inflammation balance: Helps keep pro-inflammatory pathways in check while sustaining normal repair signals—key for healthy aging tissues.
  • Mitochondrial & metabolic support: Promotes cellular “housekeeping” and energy efficiency, supporting insulin sensitivity and steady daytime energy.
  • Brain protection: Supports neuronal antioxidant capacity and normal neuroplasticity signaling—important for focus, mood, and long-term cognitive health.
  • Cardiovascular & respiratory resilience: Helps maintain supple blood vessels and supports the lungs’ natural defenses against airborne irritants.
  • Skin & environmental defense: Bolsters the skin’s response to UV and urban stressors, aiding cellular repair and barrier integrity.

Consistency compounds benefits: Small, regular signals work better than sporadic mega-doses. Aim for a dependable daily intake so protective enzymes stay “on duty.” If your meal is cooked, adding a pinch of mustard seed or mustard powder (a natural myrosinase source) can increase sulforaphane formation—often at least two-fold—amplifying the advantages without changing your routine.

How Sulforaphane Works (Active Extract)

This formula supplies active sulforaphane directly — not just the precursor. Because it is already sulforaphane, no myrosinase is required for it to be beneficial. After absorption, sulforaphane activates Nrf2, the cell’s coordination switch for defense, which in turn up-regulates intrinsic protection systems.

  • Antioxidant & detox programs: Supports Phase II enzymes (e.g., GSTs, NQO1, HO-1) and healthy glutathione recycling for everyday cellular cleanup.
  • Inflammation balance: Helps keep pro-inflammatory signaling within a healthy range while supporting normal repair processes.
  • Metabolic & mitochondrial support: Backs cellular energy production and stress resilience that underlie whole-body vitality.
  • Tissue-wide defense: Supports the body’s natural protective responses in the brain, cardiovascular system, liver, lungs, and skin.

Practical tips for active sulforaphane: Take with cool water (avoid very hot beverages around the dose), store in a cool, dry place, and consider split dosing if you’re sensitive. Mustard or other myrosinase sources are not needed for active sulforaphane; they are only useful when using glucoraphanin-only products such as broccoli, powdered, or fresh, and especially cooked broccoli.

Label check: If you have a supplement with glucoraphanin (broccoli seed/sprout extract) rather than sulforaphane, that is a precursor formula. In that case, you should pair it with a myrosinase source (e.g., a pinch of mustard powder)

 

Why standard “broccoli powder” falls short:

Many powders lack active myrosinase or are heat-processed, leaving you with glucoraphanin that does not efficiently convert to sulforaphane. Our approach specifies enzyme-active inputs so you get a reliable sulforaphane yield.

Why Foods & Seed Powders Fall Short (Consistency Matters)

Broccoli, sprouts, and broccoli seed powders are valuable foods, but their sulforaphane (sulforaphane) delivery is highly variable. Most seed/veg powders are dried or heat-processed, which can deactivate myrosinase (the enzyme that converts glucoraphanin to sulforaphane). Cooked broccoli often loses myrosinase as well, pushing conversion onto the gut microbiome—an unpredictable, low-yield pathway. Even raw produce isn’t a sure thing: seed genetics, sprout age, growing conditions, and storage can change glucoraphanin content by many fold, so yesterday’s serving may not match today’s.

  • Enzyme loss with heat: No active myrosinase → little sulforaphane formed, even if glucoraphanin is present.
  • Epthiospecifier protein diversion: Natural epithiospecifier proteins in raw brassicas (broccoli or broccoli cousins) can shunt glucoraphanin away from sulforaphane; light steaming can help, but is easy to overdo and do more damage than good, and is still inconsistent.
  • Big batch-to-batch swings: Seed variety & sprout handling can differ 5–10× in regard to glucoraphanin; most powders don’t disclose enzyme activity or verified sulforaphane yield.
  • Portion practicality: Reaching meaningful sulforaphane may require large, daily amounts of fresh sprouts or carefully prepared broccoli—hard to sustain and tough on sensitive digestion.
  • Storage degradation: Time, heat, and moisture chip away at enzyme activity and precursors in bulk powders and pre-prepped foods.

Active sulforaphane extract solves these gaps: it delivers sulforaphane itself (no enzyme required), providing a consistent, measured dose day after day. If you enjoy foods, keep them as a bonus: use raw or lightly steamed broccoli/sprouts and, when cooked, add a small pinch of mustard powder for enzyme support. For dependable results, rely on active sulforaphane; for culinary variety, let the kitchen play backup.

How Doublewood Sulforaphane is Made

Sulforaphane is activated when the inactive form of sulforaphane (broccoli seed extract) comes into contact with myrosinase.

Inactive sulforaphane is found in all cruciferous vegetables such as broccoli or cauliflower but especially concentrated in the seeds. As found in foods sulforaphane is primarily in the inactive form known as glucoraphanin or sulforaphane glucosinolate. It becomes activated in a chemical reaction involving contact with myrosinase. Our Sulforaphane is extracted from broccoli seeds. Our extraction process utilzes myrosinase which activates the sulforaphane so when it is taken as a supplement it is well absorbed and ready to take effect without need supplemental sources of myrosinase such as mustard seeds (which are high in myrosinase).

Real Stories

Sulforaphane Experiences From Everyday People

Anecdotal reports collected from public forums, store reviews, and personal blogs. Individual results vary.

Clearer mornings and easier socializing

Several users who take our sulforaphane supplements describe a lift in morning energy, less brain fog, and feeling more at ease in conversation. A common theme is that benefits fade when they stop and return when they restart.

Cool, minty head sensation & calmer days

"About 90 minutes after dosing I feel a cool, minty clarity in my head. It is subtle but reliable. Sticking with sprouts daily has been a game changer for me."

Gentler digestion and less reflux

Anecdotes include calmer stomach, fewer reflux flares, and steadier digestion after adding sulforaphane capsules for a few weeks. Taking with food appears to help comfort.

Better sleep and fewer aches

Consumer reviews frequently mention sleeping more soundly, fewer nighttime leg cramps, and less morning stiffness after a few weeks of consistent use.

Easier than sprouting

Most users prefer stabilized sulforaphane capsules as an "easy habit" compared with sprouting at home, and taking mustard seeds at the same time, reporting similar benefits with less effort.

Feeling "cleaner" on heavy days

A beauty and wellness blogger with chronic challenges noted lighter "toxic" days and steadier skin comfort after adding a daily sulforaphane shot to her routine.

Starter hiccups: GI upset

A minority report stomach aches, gas, or loose stool when beginning sulforaphane. Most resolved it by lowering the dose, taking with food, or splitting morning and afternoon.

Cramping on an empty stomach

Occasional reports describe mid abdominal cramping when dosing on an empty stomach. Taking with a small meal typically prevents this.

Rare insomnia when dosed late

A few users mention feeling too alert at bedtime when they take sulforaphane late in the day. Moving the dose to morning or early afternoon usually solves it.

Tip: avoid evening dosing if you are sensitive to alertness changes.

What readers can expect to read in testimonials

  • Often noted positives: steadier daytime energy, clearer thinking, calmer digestion, and easier recovery days.
  • Common adjustments: start low, take with food, and split doses for comfort.
  • Consistency: most anecdotes report changes after 2 to 4 weeks of daily use.

Important: These are anecdotal experiences. Sulforaphane products are not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.

 

Sulforaphane Ordering Form

Comparative Retail Price: $21.95
Our Price: $19.95

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Suforaphane

Sulforaphane facts

Alpha‑Lipoic Acid bottle

How to Use Sulforaphane

Take Sulforaphane with food: 30 minutes before, or 2 hours after, meals.

Normal use: One capsule, once or twice daily.

Aggressive use: Two to three capsules capsules twice daily.

Pairs well with: quercetin, luteolin, spermidine, taurine, curcumin, and dihydroberberine.*

Notes: Sulforaphane may cause allergic symptoms in persons allergic to broccoli and may cause stomach upset if taken aggressively or on an empty stomach. In case of allergic response, discontinue use, reduce dosage, or eat with food.*

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.



Sulforaphane — Frequently Asked Questions

Why Our Sulforaphane Stands Apart

This formula supplies active sulforaphane (sulforaphane) directly. It does not rely on myrosinase (the plant enzyme) or on your gut bacteria to convert glucoraphanin. That means you get predictable sulforaphane. That's not true of broccoli or even broccoli sprouts.

  • Independent of food preparation: No dependence on raw/steamed timing, seed genetics, or enzyme catalyst add-ons (such as mustard).
  • Bypasses ESP diversion: Avoids epithiospecifier protein pathways that can shunt precursors away from sulforaphane in raw brassicas.
  • Ready to act: Once absorbed, sulforaphane engages the Keap1–Nrf2 switch and initiates the body’s intrinsic defense programs.

Standardized to a target sulforaphane output per serving (e.g., a labeled mg amount verified by analytical testing). Not a generic “broccoli powder,” this is quantified sulforaphane for repeatable, day-to-day use.

  • Per-batch verification: Identity & potency confirmed (e.g., HPLC/validated methods); Certificate of Analysis available upon request.
  • Protected potency: Low-oxygen, light-shielding packaging with desiccant helps maintain stability during shelf life.
  • Transparent label: Look for the actual sulforaphane amount per serving, not just “broccoli extract” or “glucoraphanin.”

Formulated for purity and practicality. Capsules are typically plant-based (HPMC) with just the functional carriers needed for flow and consistency.

  • Third-party tested: Identity, potency, microbial counts, & heavy metals screened against strict specifications.
  • Commonly free of: Gluten, dairy, soy, and artificial colors; non-GMO inputs.
  • Manufactured under cGMP: Quality systems for repeatable production & traceability.

Take each serving with cool water rather than a hot beverage; food is optional. Because this is active sulforaphane, you do not need to add mustard or other myrosinase sources. Many users prefer morning or midday; sensitive users can split the dose.

  • Titration: Start low if new to brassicas (broccoli extracts); increase as comfortable over 1–2 weeks.
  • Heat note: Do not mix the contents into very hot liquids; store in a cool, dry place.
  • Stacking: Commonly paired with vitamin D3/K2, magnesium, and PEOs. If using many antioxidants, consider timing them at a different meal to keep sulforaphane’s signaling distinct.

Sulforaphane is a dietary isothiocyanate best known for activating Nrf2, which coordinates the expression of protective Phase II enzymes (e.g., GSTs, NQO1, HO-1). Unlike direct antioxidants, sulforaphane signals your cells to up-regulate their own defenses, supporting redox balance, normal inflammatory tone, and healthy detox capacity.

  • Cellular defense: Supports glutathione recycling and broad stress-response pathways.
  • Everyday exposures: Helps your body handle routine oxidative & environmental challenges.
  • System-wide relevance: Nrf2 signaling operates in the liver, lungs, brain, cardiovascular system, skin, and more.

Educational note: If your label lists glucoraphanin (precursor) rather than sulforaphane, that product requires myrosinase (from foods or included enzyme) for best results. This active-sulforaphane formula is ready to work as is.

What are the best Sulforaphane Use Protocols

Always follow the serving facts on your bottle. The guidance below shows how customers commonly use sulforaphane. If new to brassicas, start low and increase as comfortable.

Cautions

Cruciferous vegetables are safe for most people, but not all. Sulforaphane is extracted from broccoli seeds.

Talk to your clinician before use if pregnant/nursing, managing thyroid concerns without adequate iodine, or taking medications where changes in detox enzyme activity could matter.

How to Use (Daily)

Provides active sulforaphane; no myrosinase required

Directions: Take one or two capsules of active sulforaphane with water, preferably with a meal. You can do two such servings, one in the morning & one mid-afternoon for smoother exposure.

What it supports: Nrf2 signaling & Phase II pathways (e.g., GST, NQO1, HO-1) that help maintain redox balance, normal inflammatory tone, and routine cellular cleanup from everyday life.

Timing tips: Sulforaphane is short-lived. Therefore, split dosing (AM/PM) often feels steadier than one large dose. Avoid very hot drinks at the same moment you swallow capsules. Store cool & dry.

Consistency cues: Anchor sulforaphane to an existing habit (first meal; vitamins tray). Most people notice changes after 2–4 weeks of steady use.

  • Common wins: cleaner energy curve, easier recovery from hard days, fewer “post-exertion” blahs.
  • Common mistakes: stopping after one week; taking only on “good days”; thinking mustard/myrosinase is needed with preformed SFN (it is not).
Short “Intensive” Phase

Why do this? A brief, higher-frequency phase can front-load support for enzyme systems, then you coast on a simpler daily plan. Great after travel, a stressful season, or when kicking off a broader reset.

Directions: If well tolerated, use the labeled serving twice daily for 14–28 days, then drop to the routine daily plan. Take with meals; consider earlier timing if you notice night-time alertness.

Support the process: Hydrate well, target 25–35 g of fiber/day (vegetables, chia, beans), and include colorful produce to provide companion phytochemicals.

  • Listen to your gut: If you feel queasy or “off,” reduce to once daily or take with a more substantial meal.
  • Not a fit? If pregnant/nursing or on meds with narrow therapeutic windows, use a gentle daily plan under professional guidance.
  • Food synergy: Enjoy crucifers freely. If you use glucoraphanin products or cooked broccoli, a pinch of mustard seed can boost SFN; with preformed SFN, this is unnecessary.
Brain-Support Use

Protocol: Take your full daily serving in the morning with breakfast. If your label supports split dosing, use a 70% AM / 30% early-PM split to avoid late-day stimulation.

Stack with: Omega-3s (DHA/EPA), magnesium glycinate, L-theanine, daylight exposure within 60 minutes of waking, and a 10–20 minute walk to “lock in” alertness.

Expectations: SFN is not a stimulant; it works by tuning cellular pathways. Re-assess focus, task-switching ease, and afternoon dip after 8–12 weeks of consistent use.

  • Deep-work ritual: Dose → bright light → short walk → 90-minute focus block.
  • Sleep matters: Protect circadian rhythm; late dosing can feel “too alert” for some.
Gentle Start

Directions: Begin with a half serving with food for 3–4 days, then increase to the full labeled amount. Prefer breakfast or lunch dosing if evenings trigger reflux.

Comfort pointers: Take with a small, non-spicy meal; avoid taking alongside very hot coffee/tea; consider ginger or chamomile tea later if your stomach feels touchy.

  • Still sensitive? Try every-other-day for a week, then step up; or split the daily amount AM/PM.
  • Product choice: If preformed SFN bothers you, some people do better with food-based approaches or glucoraphanin + myrosinase combinations taken with a larger meal.
  • Check meds: If you use acid-reducers or have ongoing GI issues, personalize your plan with a professional.

What is the difference between sulforaphane and broccoli powder?

Sulforaphane, by Doublewood, contains a sulforaphane rich extract of Broccoli seeds, that is then activated and stabilized, providing significantly more than fresh supermarket broccoli — it would take 9 cups of chopped broccoli to equal two capsules of our sulforaphane. And, that's fresh broccoli, it would take 19 pounds (95 cups) of cooked broccoli.

When should I take Sulforaphane by DoubleWood

Any time of day. If you’re sensitive, take with food. If your formula uses myrosinase, avoid very hot drinks around the dose.

Can I just eat sprouts?

Yes—fresh, properly grown broccoli sprouts can be excellent at providing glucoraphinin and myrosinase which is required to make active sulforaphane).

  • Three ounces of broccoli sprouts typically provide 20 mg of sulforaphane the same as one of our capsules.
  • Capsules offer measured, convenient dosing and avoid spoilage or contamination that is possible in sprouts.
  • Also, broccoli sprouts typically sell for anywhere from $3 to $4 per 3 oz container. So, to get the same amount of sulforaphane from broccoli sprouts you would have to pay 120 times that amount, between $360 to $480 dollars, when a bottle of sulforaphane costs $19.95. So, it's not cost effective, although broccoli sprouts are still a great food and wonderful to add to salads.

Is it safe long-term?

Cruciferous vegetables are among the most-studied foods. Most users do well with ongoing use. If you have thyroid concerns without adequate iodine, speak with your clinician. As with any supplement, discontinue if you notice discomfort.

Don't I still Need to take myrosinase?

Short answer

No. If you’re taking sulforaphane itself sulforaphane, it does not need myrosinase. Myrosinase is only required to convert the precursor glucoraphanin glucoraphanin into sulforaphane. sulforaphane is already the active isothiocyanate that triggers Nrf2 and related pathways; it’s absorbed and works without any enzymatic “activation.”

Helpful clarifications

  • glucoraphanin → sulforaphane requires myrosinase. That enzyme can come from the plant (raw broccoli/sprouts, mustard/daikon) or from gut microbes. Cooking inactivates plant myrosinase, so glucoraphanin-only foods/supplements can under-deliver unless you add an enzyme source.
  • Preformed sulforaphane is reliably bioavailable. In human crossover work, a sulforaphane-rich beverage delivered roughly ~70% of the dose (as urinary metabolites), whereas a glucoraphanin-rich beverage without active myrosinase delivered around ~5% on average.
  • Boosting cooked crucifers: If you’re using glucoraphanin-only foods/supplements, adding a little myrosinase helps a lot. For example, ~1 g powdered brown mustard with 200 g cooked broccoli increased sulforaphane bioavailability by >4× versus broccoli alone in a randomized human study.
  • Typical conversion ranges: glucoraphanin conversion by gut microbes alone often varies from ~1–40%, whereas directly ingested sulforaphane commonly shows ~70–90% recovery as metabolites in trials.

Bottom line

  • Taking sulforaphane? You don’t need mustard/myrosinase.
  • Taking glucoraphanin (broccoli seed extract) or eating cooked broccoli? Pair it with a myrosinase source (e.g., a pinch of ground mustard seed or some raw crucifer), or choose a product that includes active myrosinase.

What can I stack it with?

  • For daily defense: vitamin D3/K2, magnesium, and omega-3s.
  • For mitochondria: CoQ10, PQQ, or alpha-lipoic acid as appropriate.
  • For gentle detox routines: adequate protein, hydration, light sweat sessions, and sleep timing.

What Scientific Studies and Trials Are There Sulforaphane

Grouped by area; human clinical and translational evidence prioritized. Links go to PubMed/PMC/journals.

Neurological & Behavioral

  • Autism (RCT, 44 males, 13–27y) — Sulforaphane improved behavior ratings over 18 weeks; effects waned after stop. PNAS 2014
  • Autism (RCT, 57 children) — 15-week double-blind trial with biomarker readouts; reports clinical change and safety. Molecular Autism 2021
  • Autism (RCT) — 36-week randomized, double-blind, placebo-controlled pediatric study. Nutrients 2023
  • Autism (Systematic review/meta-analysis) — Synthesizes RCTs; signals benefit with good tolerability. EXCLI Journal 2025
  • Brain glutathione (healthy adults) — 7-day oral Sulforaphane raised blood GSH; exploratory 7-T MRS in brain regions. Molecular Neuropsychiatry 2018
  • Schizophrenia (first-episode, randomized) — Cognitive/clinical endpoints; explores Sulforaphane’s epigenetic effects. Schizophrenia Bulletin Open 2022
  • Schizophrenia (open-label) — Pilot signals for cognitive domains with Sulforaphane-rich broccoli sprout extract. Clin Psychopharmacol Neurosci 2015

Metabolic & Diabetes

  • Type 2 diabetes (RCT) — Sulforaphane-rich extract reduced hepatic glucose production and improved glycemic control in a subgroup. Sci Transl Med 2017

Gastrointestinal (Helicobacter pylori)

  • H. pylori (human volunteers) — 7-day broccoli sprouts; mixed eradication, reduced antigen in some. Dig Dis Sci 2004
  • H. pylori density (clinical study) — Broccoli sprout extract lowered infection density markers. Gut & Liver 2015

Environmental Detoxification

  • Air pollution detox (RCT, ~300 adults) — Daily broccoli-sprout beverage increased benzene & acrolein mercapturic acid excretion. Carcinogenesis 2014
  • Benzene detox (dose-finding RCT) — Identified effective beverage concentration for enhancing benzene detoxication. Am J Clin Nutr 2019
  • Smokers (randomized crossover) — BSSE (Avmacol®) increased detoxification of tobacco carcinogens (SPMA, etc.). Cancers 2022
  • Aflatoxin biomarkers (RCT) — Broccoli-sprout infusion modulated aflatoxin & PAH biomarkers in high-risk region. Cancer Epidemiol Biomarkers Prev 2005

Respiratory & Airway

  • Upper airway (placebo-controlled, dose-escalation) — Oral Sulforaphane increased Phase II enzyme mRNA in nasal cells. Clin Immunol 2009
  • Diesel exhaust challenge — Sulforaphane-rich broccoli sprout extract attenuated nasal allergic response. Food & Function 2014
  • Asthma (RCT) — Broccoli sprouts vs. alfalfa; antioxidant gene expression & airway measures explored. JACI: In Practice 2016
  • Ozone exposure model (proof-of-concept) — Broccoli sprout homogenate did not induce antioxidant genes nor protect vs. neutrophilia. Respir Res 2016
  • COPD (RCT) — 4-week oral Sulforaphane (25 or 150 µmol/day) did not upregulate Nrf2 target genes; well tolerated. PLoS ONE 2016

Dermatology & Photoprotection

  • Topical Sulforaphane (human skin) — Broccoli-sprout extract reduced UV-induced erythema (endogenous protection vs. sunscreen-like blocking). PNAS 2007
  • Phase-2 enzyme induction (human) — NQO1 induction documented in Sulforaphane-treated human skin. Cancer Epidemiol Biomarkers Prev 2007

Oncology (Prostate focus)

  • Biochemical recurrence after prostatectomy (RCT) — 60 mg/day stabilized Sulforaphane for 6 months modulated PSA kinetics. Cancer Prev Res 2015
  • Recurrent prostate cancer (Phase II) — 200 µmol/day Sulforaphane-rich extract; safety and PSA-doubling-time analyses. Invest New Drugs 2015

Pharmacokinetics, Bioavailability & Safety

  • Phase I safety/PK (broccoli sprouts) — Tolerance & metabolism characterized in healthy volunteers. Nutr Cancer 2006
  • Bioavailability (crossover) — Compared Sulforaphane yield from glucoraphanin beverages with/without myrosinase. Cancer Prev Res 2011
  • Myrosinase matters — Active myrosinase co-delivery boosts Sulforaphane formation from glucoraphanin. Nutrients 2015
  • Gastric acidity & Sulforaphane formation — PPI (omeprazole) context explored for glucoraphanin → sulforaphane conversion. Nutrients 2019
  • HDAC inhibition (human PBMCs) — Single broccoli-sprout serving inhibited HDAC activity 3–6 h post-intake. Exp Biol Med 2007
  • Human Sulforaphane kinetics — Plasma Sulforaphane & metabolites quantified; elimination profile described. J Agric Food Chem 2008
  • Thyroid safety — Long-term sulforaphane-rich beverage showed no adverse thyroid impact in adults. Toxicol Appl Pharmacol 2019
  • Stabilized Sulforaphane tablet (Phase I, SFX-01) — 7-day dose-escalation; safety, tolerability & PK characterized. Eur J Clin Pharmacol 2024
  • Analytical method (LC–MS) — High-throughput assay for Sulforaphane & metabolites in human plasma. Molecules 2020

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The information on this website is intended as a sharing of knowledge and information from the research and experience of the Healthy-Living.Org staff and contributors. It is not intended to replace a one-on-one relationship with a qualified health care professional and it is not intended as medical advice. You should not use the information on this site for diagnosis or treatment of any health problem or for modification of any medication regimen. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before starting or discontinuing any medication, or if you suspect you have a health problem. You should keep in mind that cited references to ongoing nutritional scientific study are most likely not accepted by the FDA as conclusive. These references and mentions of benefits experienced by others are disavowed as product claims and are only included for educational value and as starting points for your own research. No food or supplement can be considered safe for all individuals. What may benefit 999,999 of a million people may harm you. Therefore, no one can take responsibility for your health except you in concert with your trusted health professional.