Dr. Robert Keller Resume

— Robert H. Keller, MD, MS, FACP, AAHIVS

Education and Training:

• 1966 Bachelor of Arts in Biology Master of Science in Biology Fordham University, Bronx, New York
• 1966 Bachelor of Arts in Biology Master of Science in Biology Fordham University, Bronx, New York
• 1970 Doctor of Medicine (MD) with honors Temple University, Philadelphia, Pennsylvania
• 1970-1974 Internship, Resident and Senior Resident University of Rochester, Rochester, New York
• 1974-1976 Fellow and Senior Fellow Department of Immunology Mayo Clinic, Rochester, Minnesota
• 1976 Master of Science in Immunology Mayo Graduate School of Medicine Rochester, Minnesota

Professional and Faculty Positions:

• 2006 Founder, CSO and Director of Medicine KBK Institute of Advanced Medicine Hollywood, Florida
• 2001 Founder, Chairman, CEO & CSO Phoenix BioSciences which has developed a new first in class and first in man viral-host interaction inhibitor for HIV / AIDS
• 1999 Founder, Chairmain,CEO and CSO Vitimmune, Inc Hollywood, Florida
• 1998 Voluntary Adjunct Professor Miller School of Medicine, University of Miami Miami, Florida
• 1996 Chairman and CEO Immune Balance Technologies Hollywood, Florida 
  1994-2006 Director of Medicine & Research BIODORON Medical Center Hollywood, Florida
• 1994-1995 Consultant in Immunology and Hematology Health Professionals, Inc and Center for Special Immunology
• 1992-1995 Director Immune Reconstitution Program Center for Special Immunology
• 1992-1995 Medical Director Center for Special Immunology Miami Beach, Florida
• 1987-1996 President and Medical Director The Wilson Bode Center Fort Lauderdale, Florida
• 1986-1987 Associate Director of Research and Development Coulter Immunology Coulter Electronics, Inc., Hialeah, Florida 
• 1982-1986 Medical Director Wilson Bode Center for Hematology and Immunology Research Milwaukee, Wisconsin 
• 1982-1986 Clinical Professor Department of Health Sciences (Hematology, Immunology, Flow Cytometry) University of Wisconsin Milwaukee, Wisconsin 
• 1982-1986 Associate Professor Departments of Medicine and Biophysics Medical College of Wisconsin Milwaukee, Wisconsin 
• 1982-1986 Clinical Investigator and Staff Physician Zablocki VAMC Milwaukee, Wisconsin 
• 1980-1982 Director of Immunology Midwest Children's Cancer Center (Immunology, Flow Cytometry, Transplantation) Chief of Immunology Milwaukee Children's Hospital Milwaukee, Wisconsin 
• 1980-1982 Associate Professor Department of Pediatrics (Hematology/Oncology, Immunology) Medical College of Wisconsin Milwaukee, Wisconsin 
• 1979-1982 Clinical Associate Professor Department of Health Sciences (Hematology, Immunology, Flow Cytometry) University of Wisconsin Milwaukee, Wisconsin 
• 1978-1980 Research Associate and Staff Physician Research Service Zablocki VAMC Milwaukee, Wisconsin 
• 1977-1980 Assistant Professor Department of Medicine (Hematology/Oncology) Medical College of Wisconsin Milwaukee, Wisconsin 
• 1977 Consultant And Assistant Professor Department of Immunology Mayo Medical School Dept. of Medicine University of Minnesota 
• 1974-1977 Fellow and Senior Research Fellow in Immunology Mayo Clinic Foundation Mayo Graduate School of Medicine Rochester, Minnesota 

Hospital Staff Appointments:

• 1976-1977 Mayo Clinic, Rochester, Minnesota 
• 1977-1986 Zablocki VAMC, Milwaukee, Wisconsin 
• 1977-1986 Milwaukee County Medical Complex, Milwaukee, Wisconsin 
• 1992-1997 Mount Sinai Medical Center, Miami Beach, Florida 
• 1992-1999 Cleveland Clinic Hospital, Fort Lauderdale, Florida 
• 1992-1999 Miami Heart Institute, Miami Beach, Florida 
• 1997-1999 Palmetto General Hospital, Hialeah, Florida 
• 1997- 2005 South Shore Hospital, Miami Beach, Florida 
• 1997- 2005 Memorial Medical Center, Hollywood, Florida 
• 1992- Broward General Medical Center, Fort Lauderdale, Florida 
• 1997- Hollywood Medical Center, Hollywood, Florida 

Fellowships and Awards:

• 1997- Hollywood Medical Center, Hollywood, Florida 1967-1969 Health Professions Scholarship
• Temple University School of Medicine 
• 1974-1975 Mayo Foundation Research Fellowship
• Mayo Graduate School of Medicine 
• 1975-1978 National Arthritis Foundation Fellowship 
• 1978-1981 VA Career Development Award, Research Associate 
• 1983-1986 VA Career Development Award, Clinical Investigator 

Grant Support during Academic Tenure

• 1978-1980 Alpha-fetoprotein Immunoregulation in a Model of Murine Lymphoma Veterans Administration Research Principal Investigator $210,000 
• 1981-1986 Immunoregulatory Dysfunction in Non-Hodgkin's Lymphoma NIH, NCI Principal Investigator $430,000 
• 1982-1986 Immunologic Studies of Environmental Lung Disease NIH (NIAID) Co-Principal Investigator $525,000 
• 1983-1986 VA Career Development Award Clinical Investigator $240,000 
• 1984-1986 Clinical Applications of Laser Flow Cytometry Principal Investigator NIH (RR Shared Equipment Program) $105,609 
• 1984-1987 Immunoregulatory Dysfunction Principal Investigator VA $245,000 
• 1985-1986 Monoclonal Antibodies in the Detection of Cervical Carcinoma Co-Principal Investigator Hillman Foundation $85,000 
• 1986-1987 Isoprinosine Modulation of the Immuno- Regulatory Imbalances in AIDS and ARC Principal Investigator of FDA IND Newport Foundation $125,000 
• 1986-1987 Isoprinosine Modulation of the Immuno- Regulatory Imbalances in AIDS and ARC Principal Investigator of FDA IND Newport Foundation $125,000 

Honors:

• 1970 Alpha Omega Alpha Temple University, School of Medicine 
• 1970 Medical Degree with honors Temple University, School of Medicine
• 1979 Superior Performance Award in Research Veterans Administration
• 1980 Fellow, American College of Physicians 
• 1991 Who's Who in Science and Technology 
• 1994 Who's Who in the World 
• 1996 Who's Who in Medicine and Science 
• 1998 HIV Medical Professional of the Year PWAC, Broward County, Florida 
• 1999 Humanitarian of the Year National Hemophilia Foundation 
• 2001 2000 Outstanding Scientists of the 21st Century 
• 2002 1000 Great Americans of the 21st Century 
• 2003 America's Top Physicians in Internal Medicine, Immunology and Hematology 
• 2004 Elected to Board of Governors Academy of HIV Medicine of the State of Florida:
• 2004 AMA Physicians Recognition Award 
• 2005 Greatest Scholars of the Twenty First Century 
• 2006 Health Professional of the Year Invited Lectureships: 
• 1977 Second Fogarty International Conference on Neonatal Liver Disease Baltimore, Maryland 
• 1977 International Conference on the Diagnosis and Prevention of Neural Tube Defects Los Angeles, California 
• 1977 Second International Conference on Diagnostic Immunology Henniker, New Hampshire 
• 1979 Radio immunochemical Detection of Cancer Albuquerque, New Mexico 
• 1980 Visiting Professor of Hematology University of Mississippi Jackson, Mississippi 
• 1981 Visiting Professor of Hematology University of California Irvine, California 
• 1981 Third International Conference on Diagnostic Immunology, Section Chair 
• 1982 Visiting Professor of Pathology University of Texas Medical Branch Galveston, Texas 
• 1983 Visiting Professor of Medicine Wilfred Hall Air Force Research Center Galveston, Texas 
• 1984 Visiting Professor Max Plank Institute for Biochemie Munich, Germany 
• 2005 Visiting Professor of Immunology and Pharmacology Peking Union Medical School (University of Beijing) Beijing, China

Editorial Boards:

• 1986-1990 Diagnostic Immunology 
• 1984-1986 Journal of Leukocyte Biology 
• 2005 Interventions in Aging 

Reviewer:

• 1990-Present Journal of Immunology 
• 2005 Interventions in Aging 

Consultant ships:

• Coulter Epics 
• Coulter Immunology 
• Corning Scientific 
• National Aeronautics and Space Administration (NASA) 
• Abbott HIV Advisory Board 
• Baxter Advisory Board for Hemophilia 
• Baxter Advisory Board for Hemophilia Inhibitor Patients 
• Consultant in Cancer Therapy, PRSS-J, Tokyo, 2005 
• Medical Advisory Council, American Federation of Hemophilia, 2002 

Board of Director Appointments:

• 2006 Member American Academy of HIV Medicine 
• 2006 Member Biosource Therapeutics 
• 2001 Chairman, Phoenix Bioscience 
• 1999 Chairman, VitImmune 
• 1996 Chairman, IBT 
• Scientific Advisory Boards:
• 2006 Cytodyn Inc 
• 2006 Acthelon Medical 
• 2006 Bioscource Therapeutics 

Certifications:

• National Board of Medical Examiners, 1971 and 1990 
• American Board of Internal Medicine, 1974 
• American Academy of HIV Medicine, 2001 
• American Academy of Anti Aging Medicine 2006 

Current Medical Licensure:

• New York #112195 
• Wisconsin #19121 
• Florida #58991 

Certification:

• ACLS 1990 
• ATLS 1990 

Professional Societies:

• Alpha Omega Alpha 
• American Association for the Advancement of Science 
• American Association of Immunologists 
• American College of Physicians 
• American Federation of Clinical Research 
• American Society of Clinical Pathology 
• American Society of Hematology 
• International Society of Hematology
• International Society of Hematopathology 
• International Immunocompromised Host Society 
• International Society of Analytical Cytology 
• Clinical Cytometry Society 
• New York Academy of Sciences 
• Clinical Immunology Society 
• National Organization for Rare Disorders 
• American Academy of Anti Aginig Medicine 

Teaching Experience:

• 1978-1980 Survey in Basic and Clinical Immunology Department of Medicine Medical College of Wisconsin 
• 1980-1983 Principles of Laser Flow Cytometry Department of Health Sciences University of Wisconsin 
• 1981 Special Topics in Immunology Immunoregulation in Cancer Department of Biology Marquette University 
• 1983-1986 Co-Director Flow Cytometry Program University of Wisconsin Introduction to Flow Cytometric Analysis Principles of Image and Laser Cytometry Hybridomas and Monoclonal Antibodies Laboratory Evaluation of Immunoregulation Clinical Immunophenotyping and DNA Analysis Advanced Cytometry Advanced Cytometric Techniques 

Invited Professional Lectures:

• Since 1979 - Dr. Keller has been the invited speaker at more than 2500 state, regional, National, and international, medical and scientific seminars and workshops In the fields of:
•   AIDS and Immunoregulation
•   Clinical Immunology
•   Chronic Fatigue Syndrome and Fibromyalgia
•   Autoimmune Disease and Control of Aberrant Immune Response
•   Nutrition and the Immune Response
•   Hormones and the Immune Response
•   Hepatitis C
•   Hemophilia
•   Protecting the Immune System Before, During, and After
      Cancer Therapy
•   Age Management
• 2000-2002 Host of Today's Health, WAXY 790 and Web streamed at Vitimmune.com and RobKellermd.org 
• 2005-2006 Host of Voice America Web Based Interactive Radio Show, The Path to Wellness and Youth 

Committee Service:

• 1985-1986 Veterans Administration Development Research and Committee Clement J. Zablocki VAMC
• 1986-1989 VA Oncology Merit Review Board 
• 1984-1986 International Society For Analytical Cytology: Research and Development 
• 1983-1986 Controls & Standards University of Wisconsin: Co Chair Flow Cytometry 
• 1983-1986 National Institutes of Health: Special Immunology Review Council Study Section 
• 1980-1982 Medical College of Wisconsin Faculty Welfare Committee 
• 1980-1982 Animal Care Committee 
• 1982-1986 Flow Cytometry Protocol Committee 
• 1992 Cancer Committee for Hollywood Medical Center 
• 1998 Committee of Ten Thousand Medical Advisory Board 
• 1996 National Hemophilia Federation: Medical Advisory Committee 
• 1994 National Hemophilia Foundation- Florida Chapter Medical Advisory Committee 
• 1994-1997 Mount Sinal Medical Center Cancer Committee 
• 2001 Hollywood Medical Center Cancer Committee 
• 2005 Underwriting Committee ProAssurance Malpractice 
• 2005 AAHIVM Standards of Practice Committee 

  Statement of Research Interest:

• HIV: Dissection of the immune perturbations Associated with HIV infection including therapy with experimental immunomodulary agents. 
• Dissection of the immune perturbations Associated with hemophiliac complication and therapeutic intervention using experimental immunoregulatory agents. 
• Creation and utilization of unique `designer` monoclonal antibodies for the diagnosis, monitoring, imaging and therapy of human hematologic and solid tumor malignancies. 
• Immune response and immunoregulation: dissection of the basic human immune response and the roles of cytokines and other regulatory molecules and the demonstration and characterization of aberrant responses in neoplastic and immunologic disease. 
• Nutritional/ Hormonal Supplementation in Age Management and Immunologic Disease 

 Patents Issued:

• R.H. Keller and Dr. X. Wen: Allerg-ease (Patent Number 6,180,106) (2000) 
• R.H. Keller, D.W. Kirchenbaum: ALL-Immune (Patent Number 6,262,019) (2002) 
• R.H. Keller, PBS 119 a novel treatment for chronic viral infections (Patent Number 6,734,192) (2004) 

 Patents Pending:

• Keller R.H. A novel treatment For Viral Infections (CIP) 2005 
• Keller RH: An improved method for glutathione production in mammals 2007 
• Keller RH: A nutritional formula to promote weight loss in mammals 
• Keller RH: A novel treatment for neurodegenerative diseases 
• Keller RH: A nutritional formula to improve short term memory function 

 Books:

• Keller, R.H. After Thirty, Some Maintenance Is Required-A Practical Guide to Age Management 

 Book Chapters:

• Keller, R.H. and Tomasi, T.B.: Alpha-fetoprotein: A Potential Regulator of Immune Function. In Diseases of the Liver and Biliary Tract. Javitts, N.NIH, Bethesda, Maryland, pp. 119-134, 1977. 
• Keller, R.H., Calvinico, N.J., Fink, J.N., and Stevens, J.O.: Immunobiologic Aspects of Primate Hypersensitivity Pneumonitis. In Environmental Toxicology. Dungworth, D.L. (Ed), Academic Press, New York, pp.383-395, 1981. 
• Keller, R.H., Blake, D.G., Lyman, S. and Siebenlist, R.: The Immunobiology of Human Non-Hodgkin's' Lymphomas. In Clinical Cellular Immunology. Ludered, A. (ed). Humana Press, New York, pp. 213-246, 1982. 
• Patrick, C.W., Keller, R.H., and Horan, P.K.: Flow Cytometry, Cell Sorting and Hybridomas. American Society Clinical Pathology Press. St. Louis, MO, pp. 1-182, 1982. 
• Patrick, C.W., Parker, J., Keller, R.H., and Horan, P.K.: The Clinical Utility of Monoclonal Antibodies and Immunophenotyping. In Flow Cytometry and Cell Sorting in Hematologic Disease. American Society of American Pathologists Press. Chicago, IL pp. 1-191. 
• Calvinico, N.J., Fink, J.N., and Keller, R.H.: Hypersensitivity Pneumonitis. In The Immunology of the Lung. Bienenstock, J. (Ed), Academic Press, New York pp 365-366, 1984 
• Keller, R.H., Milson, T.J., Janicek, K.M., Patrick, L.C., Sohnle, P., and Patrick, C.W.: Clinical Utilization of the Technicon H-6000 Flow Cytochemical Flow System in Allergy Testing. In Proceedings of the 4th International Technicon Hematology Colloquium. Simson, E. (ed) Academic Press, New York, pp 179- 188, 1984. 
• Patrick, C.W., Horan, P.K, and Keller, R.H.: Immunophenotypic and Functional Analysis Using Laser Flow Cytometry: Clinical Utility. American Society of Clinical Pathology Press, Chicago, IL, 1985, pp. 1-168. 
• Patrick, C.W. and Keller, R.H.: Lymphocytes: Biochemistry, Physiology, Function and Morphology. In Principles of Hematology: Clinical and Laboratory Practice. R.L. Bick, (Ed) C.V. Mosby, St. Louis, MO in press. 
• Patrick, C.W. and Keller, R.H.: The Emerging Role of Laser Flow Cytometry and Monoclonal Antibodies in Clinical Medicine. In: Principles of Hematology: Clinical Laboratory Practice. R.L. Bick (Ed) C.V. Mosby, St. Louis, MO, in press. 
• Keller, R.H. and Patrick, C.W.: Characterization of the Human Myeloid Series by Monoclonal Antibodies. In Monoclonal Antibodies in Laboratory Medicine. Swartz, M. (Ed) Academic Press, New York, in press. 
• Patrick, C.W., McFadden, P.W., and Keller, R.H.: Immunophenotypic Analysis of Human Bone Marrow Employing Monoclonal Antibodies and Laser Flow Cytometry. In Proceedings of the Second International Conference on Technological Advances in Laboratory Hematology. Howen, B. (ed),Academic Press, 1985. 
• Keller, R.H., Janicek, K.M., and Patrick, C.W.: The Clinical Significance of Laser Flow Cytometry DNA Analysis. In Proceedings of the Second International Conference on Technological Advances in Laboratory Hematology. Howen, B. (Ed) Academic Press, New York, 1985. 
• Keller, R.H., Van Riel, F., Maislis, J., Lane, J.T., Reiter, W.M., Klimas, N.G, Fletcher, M.A.: Association of Histocompatability Class II Antigens wit the Chronic Fatigue Immune Dysfunction Syndrome. In Clinical Infectious Disease. University of Chicago, Chicago, IL, 1994:18 (Supp 1): S154-6. 
• Antioxidants and the skin, A Paradigm for aging. Keller, R.H and E Arrayove (in press) 2004. glutathione in Aging and Immunologic Disease. Loss of Gastrointestinal During Aging and Immunologic Disease Both Ed R. Wallace and Mechanisms of Aging Dove Press N Z, 2006 
• Original Research Contributions and Invited Reviews: Keller, R.H. and Tomasi, T.B.: Alpha-fetoprotein, E-Rosette Formation and Tumor Cell Growth. N Engl J Med 293(24): 1265-1266, 1975. 
• Tomasi, T.B., Dattwyler, R., Murgita, R. and Keller, R.H.: Immunosuppression By Alpha-fetoprotein. Trans Am Assoc Phys. 88:293-298, 1976. 
• Geubel, A.P., Keller, R.H., Summerkill, W.H.J., Dickson, E.R., Tomasi, T.B. and Shorter, R.G.: Lymphocyte Cytotoxicity and Inhibition Studied with Autologous Liver Cells: Observation in Chronic Acute Liver Disease and the Primary Biliary Cirrhosis Syndrome. Gasterenterol. 71:450-459, 1976. 
• Keller, R.H. and Clavanico, N.J., and Tomasi, T.B.: Immunosuppressive Properties of AFP: Role of Estrogens. In Onco Developmental Gene Expression. Fichman, W.H. and Sell, S. (eds) Academic Press, New York, p.278, 1976. 
• Keller, R.H. and Tomasi, T.B.: Synthesis of Alpha-fetoprotein by Murine Lymphoid Cells in Allogenic Reactions. J Exp Med 143:1120, 1976. 
• Banks, P., Keller, R.H., Li, V.Y. and White, E.B.: Malignant Lymphomas of Plasmablastic Identity: A Neoplasm with Both "Immunoblastic" and Plasma Cell Features. Am J Med 64:609-610, 1978. 
• Keller, R.H., Atwater, J.S., Martin, R.S. and Tomasi, T.B.: Ataxia Telangiectasia, Immunosuppression and AFP: Is There a Relationship? In Prevention of Neural- Tube Defects. Crandall, B. (ed) Academic Press, New York, pp.27-40, 1978. 
• Guirgis, H.A., Lynch, H.T., Keller, R.H., Tomasi, T.B., Vandervoorde, J., Brodky, F., Lynch, J., Rankin, L. and Malony, K.: Carcinoembryonic Antigen (CEA) and Alpha-fetoprotein (AFP) in Cancer-Prone Families: Communicable Implications. In Proceeding of the Third Annual Symposium on the Detection and Prevention of Cancer. Part I (2), 1987. 
• Keller, R.H., Dattwyler, R.J., Harrison, E. and Tomasi, T.B.: Alpha-fetoprotein in Human Lymphoproliferative Disease. J Lab Clin Immunol, 2:93-98, 1979. 
• Kaplan, H.J., Meredith, T.A., Aeberg, T.M. and Keller, R.H.: Intraocular Reticulum Cell Sarcoma (Histiocytic Lymphoma) in Richter's Syndrome: A Neoplasm of the Immune System. Arch Opthal 98:707-710, 1980. 
• Keller, R.H., Blake, B.G., Lyman, S. and Siebenlist, R.: ImmunoregulatoryAbnormalities in Chronic Lymphocytic Leukemia. J Lab Clin Immunol 6:201-208, 1981. 
• Choi, H. and Keller, R.H.: Co-existence of Chronic Lymphocytic Leukemia and Hodgkin's Disease. Cancer 48:48-55, 1981. 
• Kaplan, H.J., Aeberg, T.M. and Keller, R.H.: Etiology of Recurrent Clinical Uveitis. Ber Dtsch Ophthal Ges 78:159, 1981.