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Doubl wood Magnesium Acetyl Taurate Magnesium Taurate by Double Wood Magnesium L-Threonate by Double Wood Magnesium Complex by Double Wood

Low Magnesium Drains Your Energy, Clouds Your Mind, and Speeds Up Aging — Learn Which Form Can Help You Rebuild Today.

🧪 People who understand biochemistry know that magnesium is nothing less than the spark plug of cellular energy production — without it, ATP can't function.

And energy? Well, energy is the only true wealth the human body has.

Unfortunately, magnesium has been depleted from soils and produce. This requires smart people to supplement with magnesium so that their cells don't run short on energy.

Magnesium isn’t just important — it’s foundational.

It drives the cellular processes behind energy production, restorative sleep, cognitive performance, and detoxification. But new insights reveal that it’s not just having enough magnesium that matters — it’s the form you choose that determines how and where it works in your body.

Forms like Magnesium Acetyl Taurate, Magnesium L-Threonate, Malate, and Ascorbate each target different systems — from brain to heart to mitochondria — making your choice of magnesium a strategic one.

⚙️ Why Magnesium is Biochemically Irreplaceable

Magnesium is essential to cellular function because it acts as a cofactor in over 300 enzymatic reactions, including those involved in ATP production, DNA/RNA synthesis, and protein formation. It stabilizes ATP — the cell’s energy currency — by binding to it to form the biologically active complex Mg-ATP.

Magnesium’s unique ionic radius and charge density enable it to regulate calcium flow in and out of cells, preventing excitotoxicity and supporting both nerve and muscle balance. Unlike other ions, magnesium can bridge phosphate groups and shield negative charges in nucleotides and enzymes, making it truly irreplaceable in energy transfer, genetic stability, and cellular communication.

❓ Why Do We Offer Several Different Magnesium Products?

Because different magnesium compounds function differently, they're not the same in their effect  — and not everyone’s body has the same needs.

Each form of magnesium is bonded to a different molecule, which affects how it's absorbed and which cells or tissues can utilize it most effectively. Some forms are better for the brain, others for the heart, muscles, digestion, or even the immune system.

  • Magnesium Acetyl Taurate: Offers brain-targeted support, as well as cardiovascular support, often chosen by those focused on long-term neurological health and resilience.
  • Magnesium Taurate: Supports a healthy heart and promotes nervous system balance — ideal for those seeking calm focus and cardiovascular strength.
  • Magnesium L-Threonate: Crosses the blood–brain barrier and supports learning, memory, and cognitive clarity.
  • Magnesium Glycinate: Promotes relaxation and sleep — ideal for stress and muscle tension.
  • Magnesium Malate: Supports energy production and physical stamina — great for fatigue and muscle recovery.
  • Magnesium Citrate: Helps with digestive regularity and gentle magnesium replenishment.
  • Magnesium Orotate: Delivers magnesium deep into cells — often used for heart function and endurance.
  • Magnesium Ascorbate: Combines magnesium with vitamin C, making it especially useful for immune support and antioxidant replenishment.
  • Magnesium Complex: A combination of eight of the above forms in one capsule.

We offer these forms so you can choose the magnesium that best matches your personal health goals — or we offer a combination that covers many bases.

What Unique Benefits Come From Our Various Magnesium Products

🧠 Magnesium Acetyl Taurate (TauroMag)

  • Supports brain magnesium levels, cognitive clarity, and neurological resilience.
  • Special because Magnesium Acetyl Taurate combines magnesium with acetylated taurine — a form that may cross the blood–brain barrier more effectively, supporting brain tissue directly.
  • This form is ideal for those seeking neuroprotective support, especially during periods of cognitive stress, mental fatigue, or age-related decline.

❤️ Magnesium Taurate

  • Supports heart magnesium levels, cardiovascular health, neuromuscular balance, and a calm stress response.
  • Special because Magnesium taurate combines magnesium with the amino acid taurine, known for its role in supporting healthy cell membrane function and maintaining blood pressure already within the normal range.
  • It is gentle, highly absorbable, often well-tolerated, and ideal for those seeking heart and nervous system support.

🧠 Magnesium L-Threonate (Magtein®)

  • Supports memory, learning, cognitive clarity, and long-term brain health.
  • Special because Magnesium L-Threonate is the form with the most studies showing that it effectively cross the blood–brain barrier, increasing magnesium levels in brain tissue.
  • Clinically studied for its role in supporting synaptic plasticity and mental performance, especially during aging or periods of cognitive stress.

⚡ Magnesium Malate

  • Supports cellular energy production, muscle recovery, and physical endurance.
  • Special because Magnesium Malate includes malic acid — a key compound in the Krebs cycle, the body’s natural energy-generating process.
  • Often preferred by individuals dealing with fatigue, muscle discomfort, or chronic physical stress. Best taken earlier in the day for a gentle energy lift.

😌 Magnesium Glycinate

  • Supports restful sleep, relaxation, and a balanced nervous system.
  • Special because Magnesium Glycinate is bound to glycine — a calming amino acid that enhances its soothing effects without causing drowsiness or digestive upset.
  • Highly bioavailable, gentle on the stomach, and ideal for those seeking support for stress, muscle tension, and quality sleep.

💩 Magnesium Citrate

  • Supports digestive regularity and gentle magnesium replenishment.
  • Special because Magnesium Citrate draws water into the intestines, making it helpful for promoting bowel movements and easing occasional constipation.
  • Commonly used for digestive cleansing, but also provides easily absorbable magnesium for general support — often best taken in lower doses to avoid loose stools.

💓 Magnesium Orotate

  • Supports cellular energy, heart function, and physical endurance.
  • Special because Magnesium Orotate delivers magnesium along with orotic acid, a compound involved in DNA synthesis and cellular repair — potentially enhancing magnesium delivery to heart and muscle tissues.
  • Often favored by athletes and those seeking cardiovascular support, especially during times of stress or increased physical demand.

💧 Magnesium Chloride

  • Supports deep relaxation, nervous system balance, natural detoxification, and restoring vital mineral balance, making it essential for stress recovery.
  • Special because Magnesium Chloride is one of the most soluble and bioavailable forms of magnesium. Especially helpful for those with digestive sensitivities or compromised gut absorption.
  • Commonly used to relieve physical and mental tension and support detoxification pathways. Its gentle, non-laxative nature makes it ideal for sustained, restorative use.

🍊 Magnesium Ascorbate

  • Supports immune health, antioxidant defense, and gentle magnesium replenishment.
  • Special because Magnesium Ascorbate combines magnesium with vitamin C, delivering both mineral and antioxidant benefits in a buffered, less acidic form.
  • Well-tolerated and ideal for individuals with sensitive stomachs or those looking to support immune resilience, connective tissue, and overall vitality.

🧩 Magnesium Complex)

  • Offers broad-spectrum support for energy, sleep, focus, muscle comfort, and mood.
  • Special because Magnesium Complex blends numerous highly bioavailable forms, including bis-glycinate, malate, aspartate, taurate, orotate, citrate, and threonate — to provide whole-body support across multiple systems.
  • Ideal for those looking to cover multiple wellness goals in one supplement.

Factors and Real Life Experiences You Should You Consider When Choosing a Magnesium Supplement!

Choosing the right form of magnesium is essential — but it's just one part of the equation. To get the most out of your supplement, here are several other key considerations:

  • Absorption rate: Not all forms of magnesium absorb equally well in the body. Highly bioavailable forms like magnesium glycinate, threonate, malate, and taurate tend to be absorbed more efficiently than cheaper options like oxide. Poorly absorbed forms can pass through your system with minimal benefit — or cause unwanted side effects.
  • Digestive tolerance: Some magnesium forms — especially magnesium citrate and oxide — have a laxative effect, which can be helpful for constipation but problematic for daily use. More gentle options like magnesium glycinate, taurate, or threonate tend to be easier on the stomach and better for long-term use.
  • Purpose-specific benefits: Each form of magnesium supports different systems in the body. For example, magnesium l-threonate targets the brain, taurate supports the heart and nervous system, malate enhances cellular energy, and glycinate promotes calm and sleep. Choosing based on your specific health goals yields better results.
  • Stacking potential: Magnesium blends — such as complexes containing multiple forms — can provide more complete coverage without overdosing a single form. These blends allow you to support several systems at once (e.g., brain + muscle + cardiovascular) while improving tolerance and absorption synergy.
  • Fillers & quality: Look closely at the ingredient list. Many low-cost magnesium supplements include unnecessary fillers, binders, or additives that can reduce purity or cause sensitivities. Choose clean-label brands with third-party testing when possible to ensure potency, purity, and integrity.
  • Timing & pairing: Magnesium can be taken at different times based on your goals. Magnesium L-Threonate is often best at night for brain repair and mental clarity. Malate and taurate may be better earlier in the day to support energy and cardiovascular rhythm. Pairing magnesium with nutrients like vitamin B6, vitamin C, or electrolytes can further enhance absorption and effectiveness.

The best magnesium supplement for you isn't just about the form — it's about how that form fits your body’s needs, your health priorities, and your lifestyle. With the right match, magnesium can become one of the most transformative nutrients in your daily routine.

🧪 Real-Life Magnesium Use Cases

Here are 10 example scenarios showing how individuals have combined specific magnesium forms with other nutrients to support their personal wellness goals:

🧠 1. Brain Fog & Mental Fatigue (Mid-40s Entrepreneur)

  • Stack: Magnesium L-Threonate + Lion’s Mane + CoQ10
  • Focus: Mental clarity, energy, and sustained focus
  • Experience: Reported improved alertness and better afternoon productivity

😴 2. Stress-Induced Insomnia (Late 30s Teacher)

  • Stack: Magnesium Glycinate + L-theanine + Low-dose Melatonin (as needed)
  • Focus: Restful sleep and calm evenings
  • Experience: Felt more relaxed at night with more consistent sleep

❤️ 3. Cardiovascular & Stress Support (Retired Male, 60s)

  • Stack: Magnesium Taurate + Parent Essential Oils + Hibiscus tea
  • Focus: Heart rhythm and vascular support
  • Experience: Noticed steadier energy and felt more balanced overall

⚡ 4. Persistent Fatigue & Muscle Discomfort (Woman, 50s)

  • Stack: Magnesium Malate + B-complex + D-Ribose + Acetyl-L-Carnitine
  • Focus: Cellular energy and muscle function
  • Experience: Reported more daytime stamina and less discomfort after activity

🧘‍♀️ 5. Stress & Emotional Balance (Young Mom, 30s)

  • Stack: Magnesium Glycinate + Ashwagandha + Vitamin B6
  • Focus: Calm mood and daily resilience
  • Experience: Felt more emotionally centered with fewer energy dips

🚽 6. Digestive Regularity Support (Sedentary Adult, 40s)

  • Stack: Magnesium Citrate (low dose) + SBO Probiotics + Digestive Enzymes
  • Focus: Gentle regularity and gut comfort
  • Experience: Noticed easier digestion and smoother bowel rhythm

🧩 7. General Wellness & Daily Support (Health-Conscious, 50s)

  • Stack: Magnesium Complex (multi-form) + Parent Essential Oils + Mineral Support
  • Focus: Balanced energy, brain, and body support
  • Experience: Reported more stable energy and better recovery from stress

💓 8. Nerve & Cardiac Balance (Active Woman, 60s)

  • Stack: Magnesium Taurate + Potassium-Rich Diet + Low-Dose Magnesium Orotate
  • Focus: Nervous system calm and heart support
  • Experience: Felt more electrically balanced with fewer moments of tension

🧠 9. Brain Aging Support (Cognitive Wellness, 70s)

  • Stack: Magnesium Acetyl Taurate + Curcumin + Resveratrol + Probiotic Fiber Stack
  • Focus: Brain resilience and long-term cognitive clarity
  • Experience: Reported clearer thinking and more consistent daily focus

💪 10. Athletic Recovery & Sleep Quality (Triathlete, 40s)

  • Stack: Magnesium Malate (AM) + Magnesium Glycinate (PM) + Electrolytes + Taurine
  • Focus: Recovery, hydration, and rest
  • Experience: Noticed faster post-exercise recovery and better nighttime sleep

*These examples are for educational purposes only and do not constitute medical advice. Individual experiences may vary. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Kent's Magnesium Strategy

Kent and Dr. Kellas agree on a foundational magnesium strategy: always supplement with at least three different forms of magnesium to target multiple body systems. Rotating these forms every few months helps maintain optimal absorption and effectiveness. Kent’s current three-part magnesium stack includes:

  • Magnesium Acetyl L-Taurate – optimal for brain and nerve cell support.
  • Magnesium Threonate – preferred by memory-related cells and linked to cognitive function.
  • Magnesium Complex – provides a broad spectrum of magnesium types to cover systemic needs.

After a few months, Kent replaces one of the above forms with a new variety and follows it consistently for another cycle. This rotation strategy, developed with Dr. Kellas, is believed to deliver superior long-term results for magnesium balance and bioavailability.

Few things in nutrition are more essential than maintaining excellent magnesium levels throughout all tissues and cells of the body.

Magnesium Supplements Ordering Form

Magnesium Form: 
Quantity: 

Our Magnesium Products

magnesium acetyl taurate supplement facts magnesium taurate supplement facts magnesium threonate supplement facts magnesium complex facts
Magnesium Acetyl Taurate by Double WoodMagnesium Taurate by Double WoodMagnesium L-Threonate by Double WoodMagnesium Complex by Double Wood

How to Use

  • Take one or more capsules per day.

Magnesium Supplements - Frequently Asked Questions

❓ Why Supplement With Magnesium Instead of Just Focusing on Eating More Nutritously?

Magnesium is required for over 300 enzymatic reactions in the body — including those related to energy production (ATP), muscle and nerve function, blood sugar regulation, DNA repair, and neurotransmitter balance. Yet an estimated 50–70% of people are deficient, even in developed countries.

Food Alone Often Isn’t Enough to Maintain Optimal Magnesium Levels

While magnesium is found in leafy greens, nuts, seeds, and whole grains, there are several reasons modern diets fall short:

  • Soil Depletion: Modern farming has stripped magnesium from topsoil, reducing the mineral content of produce.
  • Food Processing: Cooking and refining grains can remove 40–90% of natural magnesium content.
  • Modern Lifestyles: Stress, caffeine, alcohol, sugar, and many medications deplete magnesium stores.
  • Poor Absorption: Age, gut imbalances, and digestive issues often reduce how much magnesium is absorbed, even if you eat well.

Why Supplementing Works

  • Supplements provide measurable, bioavailable forms that correct deficiencies efficiently.
  • Different forms (glycinate, threonate, taurate, etc.) offer targeted support for brain, heart, stress, or digestion.
  • Supplementation ensures consistent intake — crucial for people with higher needs or absorption challenges.
Bottom line: While food should always be your foundation, magnesium supplementation is often necessary to reach and maintain optimal levels — especially in today’s depleted, high-stress, fast-paced world.
Magnesium Supplementation Helps One Feel Great

Magnesium supplementation helps with waking up energized and happy in the morning as well as functioning one's best all day long.


❓ What happens if you're low on magnesium and don’t even know it?

Magnesium deficiency is often called a "hidden epidemic" because the symptoms are subtle, common, and easy to blame on other things — like stress, poor sleep, or aging.

When you're low on magnesium, your cells can’t produce energy efficiently, muscles don’t relax properly, and your nervous system becomes more reactive. This can lead to symptoms like:

  • Brain fog or low focus
  • Muscle cramps, eye twitches, or restless legs
  • Trouble falling or staying asleep
  • Anxiety or irritability
  • Fatigue that doesn’t improve with rest
  • Sensitivity to noise, light, or stress
  • Cravings for chocolate, salt, or carbs (your body’s cry for minerals and especially magnesium)

Since magnesium is involved in over 300 biochemical reactions, even a small deficiency can ripple across your entire body.

And here's the kicker: blood tests often don’t catch it, because only 1% of your magnesium is in your bloodstream — the rest is stored in your bones, tissues, and cells.

So if you're experiencing any of the symptoms above, there's a good chance your body is asking for more magnesium — and you haven’t heard it clearly... until now.

❓ Can magnesium really help with energy, sleep, and stress — all at once?

Yes — and here’s why: magnesium is involved in over 300 enzymatic reactions in the body, many of which directly affect your energy levels, sleep cycles, and stress response.

  • 🧠 For energy: Magnesium is needed to convert food into ATP — the molecule your cells use for fuel. Without enough magnesium, energy production slows down at the cellular level.
  • 🌙 For sleep: Magnesium helps activate GABA receptors, which calm the nervous system and support deeper, more restful sleep.
  • 🧘‍♀️ For stress: It helps regulate the release of stress hormones like cortisol and supports neurotransmitters involved in mood balance and resilience.

What’s more, magnesium is easily depleted by stress, caffeine, sugar, and even exercise — which makes replenishing it critical for keeping these systems in balance.

So yes — magnesium really can support energy, sleep, and stress simultaneously. That’s why it’s often called the “master mineral” of modern wellness.

Studies Regarding Magnesium Supplementation of Different Forms:

The information and studies referenced on this page are provided for educational and informational purposes only. The nutrients in these supplements are intended to support normal biological functions and are not designed to diagnose, treat, cure, or prevent any disease. Any positive outcomes observed from magnesium supplementation should be understood as a reflection of the body’s natural ability to maintain balance and well-being when given the appropriate nutritional support.

Explore peer-reviewed research supporting the unique benefits of different magnesium supplements.

🧪 Research Studies on Magnesium Acetyl Taurate (MgAT)

  1. Neuroprotection in Retinal Cells
    Study: Magnesium Acetyltaurate Against NMDA-Induced Retinal Damage
    Findings: MgAT reduced retinal oxidative stress and apoptosis, suggesting neuroprotective effects in retinal ganglion cells.
    Read Study
  2. Prevention of Brain Damage Post-Trauma
    Study: MgAT in Traumatic Brain Injury Models
    Findings: MgAT ameliorated histopathological damage and improved vasopressin receptor levels in the amygdala, indicating potential in preventing structural and functional brain damage.
    Read Study
  3. Enhancement of Synaptic Plasticity
    Study: Oral Administration of MgAT on Hippocampal Function
    Findings: MgAT improved long-term potentiation in the hippocampus and increased NR2B subunit expression of NMDA receptors, suggesting benefits in cognitive function.
    Read Study
  4. Reduction of Stress and PMS Symptoms
    Study: MgAT Supplementation in Women with PMS
    Findings: Daily intake of MgAT reduced symptoms like anxiety, irritability, and depression over three menstrual cycles.
    Read Summary
  5. Superior Brain Magnesium Delivery
    Study: Comparative Analysis of MgAT and Other Magnesium Forms
    Findings: MgAT showed higher brain tissue magnesium levels compared to other forms like citrate and malate, indicating enhanced bioavailability.
    Read Summary

🫀 Research Studies on Magnesium Taurate

  1. Antihypertensive and Cardioprotective Effects
    Study: Magnesium taurate attenuates progression of hypertension and cardiotoxicity against cadmium chloride-induced hypertensive albino rats
    Findings: Oral administration of magnesium taurate significantly restored blood pressure, enhanced myocardial antioxidant levels, and reduced heart tissue damage in hypertensive rats, indicating its potential as a cardioprotective agent.
    Read Study
  2. Prevention of Cataractogenesis
    Study: Magnesium taurate prevents cataractogenesis via restoration of lenticular oxidative damage and ATPase function in cadmium chloride-induced hypertensive experimental animals
    Findings: Magnesium taurate supplementation prevented cataract formation by restoring blood pressure, reducing oxidative damage in the lens, and improving lens ATPase activity in hypertensive rats.
    Read Study
  3. Vascular-Protective Actions
    Study: Complementary vascular-protective actions of magnesium and taurine: a rationale for magnesium taurate
    Findings: The combination of magnesium and taurine in magnesium taurate may offer synergistic effects in reducing blood pressure, preventing arrhythmias, and providing vascular protection, suggesting its potential as a nutritional supplement for cardiovascular health.
    Read Study
  4. Potential in Managing Hypertension
    Study: The Promising Role of Magnesium Taurate in Managing Hypertension
    Findings: Magnesium taurate may assist individuals with hypertension in reducing their blood pressure, highlighting its potential benefits in managing this condition.
    Read Study
  5. Benefits in Anxiety and Mental Health
    Study: Best Forms of Magnesium for Anxiety and Depression
    Findings: Magnesium taurate and glycinate have the most research supporting their effects on anxiety and other mental health disorders, suggesting their potential use in managing these conditions.
    Read Study

🧠 Research Studies on Magnesium L-Threonate (MgT)

  1. Enhancement of Cognitive Function in Healthy Adults
    Study: A Magtein®, Magnesium L-Threonate-Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
    Findings: In a double-blind, placebo-controlled study, subjects receiving Magtein®PS showed significant improvements over the control group in all five subcategories of “The Clinical Memory Test” as well as the overall memory quotient scores. Older participants showed more improvement than younger participants.
    Read Study
  2. Neuroprotective Effects Against Oxidative Stress
    Study: Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer’s disease mouse model
    Findings: MgT prevented Aβ-induced oxidative stress damage by elevating cell viability and decreasing ROS formation and apoptosis in HT22 cells. In APP/PS1 mice, MgT ameliorated cognitive deficits and suppressed hippocampal neuronal apoptosis.
    Read Study
  3. Improvement in Sleep Quality and Daytime Functioning
    Study: Magnesium-L-threonate improves sleep quality and daytime functioning in adults with poor sleep quality
    Findings: MgT supplementation improved sleep quality, particularly deep/REM sleep stages, and enhanced mood, energy, alertness, and daily productivity.
    Read Study
  4. Potential Benefits in Mild to Moderate Dementia
    Study: Magnesium L-Threonate for the Enhancement of Learning and Memory in People With Dementia
    Findings: This clinical trial aimed to examine the effects of MgT supplementation in individuals with mild to moderate dementia, focusing on improvements in memory and brain function.
    Read Study
  5. Enhancement of Synaptic Density and Cognitive Function
    Study: Enhancement of Learning and Memory by Elevating Brain Magnesium
    Findings: MgT supplementation increased synaptic density in regions of the brain associated with memory, leading to improvements in short-term and long-term memory in animal models.
    Read Study

🧪 Research Studies on Magnesium Orotate

  1. Improvement in Severe Congestive Heart Failure
    Study: Magnesium orotate in severe congestive heart failure (MACH)
    Findings: In a double-blind study, patients with severe heart failure receiving magnesium orotate showed a higher survival rate (75.7%) compared to placebo (51.6%) and improved clinical symptoms over one year. Read Study
  2. Enhancement of Exercise Tolerance in Coronary Heart Disease
    Study: Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease
    Findings: A 4-week double-blind trial demonstrated that magnesium orotate supplementation improved left ventricular function and increased exercise duration in patients with coronary heart disease. Read Study
  3. Cardioprotection During Ischemia-Reperfusion
    Study: Magnesium orotate elicits acute cardioprotection at reperfusion in rat hearts
    Findings: Administration of magnesium orotate at the onset of reperfusion preserved myocardial function and reduced infarct size in rat models, suggesting its potential in acute cardiac events. Read Study
  4. Modulation of Gut-Brain Axis in Neuropsychiatric Disorders
    Study: Magnesium Orotate and the Microbiome–Gut–Brain Axis Modulation
    Findings: Review suggests that magnesium orotate may aid in treating gastrointestinal and psychiatric symptoms by modulating the gut–brain axis, especially when combined with probiotics. Read Study
  5. Adjunctive Treatment in SSRI-Resistant Depression
    Study: Combination of probiotics and magnesium orotate attenuates depression in SSRI-resistant patients
    Findings: An 8-week pilot study showed that adding magnesium orotate and probiotics to SSRI treatment improved depression symptoms in patients unresponsive to SSRIs alone. Read Study
  6. Reduction of Stress Response in Athletes
    Study: On the significance of magnesium in extreme physical stress
    Findings: Magnesium orotate supplementation in athletes reduced stress-induced hormonal responses and improved glucose utilization without affecting performance. Read Study
  7. Meta-Analysis on Cardiovascular Benefits
    Study: Meta-analysis of clinical trials of cardiovascular effects of magnesium orotate
    Findings: Analysis of 19 randomized studies indicated that magnesium orotate supplementation reduced risks of arrhythmias, hypertension, and improved autonomic function. Read Study

😌 Magnesium Glycinate

  • Sleep & Anxiety: Magnesium glycinate may benefit mild anxiety and insomnia, especially in those with low baseline magnesium.
    View study on NIH.gov
  • Sleep Quality: A systematic review confirms magnesium’s role in various aspects of sleep health.
    View study on PubMed
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